Welcome to the CRRT Online Faculty Center!

Matthias Kretzler, Ann Arbor, MI US Dr. Kretzler is the Warner-Lambert/Parke-Davis Professor of Internal Medicine/Nephrology and Computational Medicine and Bioinformatics. The overarching goal of his research is to define kidney disease in mechanistic terms and use this knowledge for targeted therapeutic interventions. To reach this goal he has developed a translational research pipeline centered on integrated systems biology analysis of renal disease. He leads together with Dr. Himmelfarb the NIDDK Kidney Precision Medicine (KPMP) Central Hub and Kidney Mapping Atlas Project (KMAP), the Nephrotic Syndrome Research Network (NEPTUNE), is a Principle Investigator (PI) of the Breakthrough T1D (former JDRF) Center of Excellence at the University of Michigan, the PI of the Renal Precompetitive Consortium. He has 30 years of experience in integration of bioinformatics, molecular and clinical approaches in more than 450 publications. He has a track record on interdisciplinary data integration of large-scale data sets in international multi-disciplinary research networks in the US, Europe, Asia and sub-Saharan Africa. These studies enable precision medicine across the genotype-phenotype continuum using carefully monitored environmental exposures, genetic predispositions, epigenetic markers, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histological biopsy archive and prospective clinical disease characterization. The molecular mechanism identified have result in new disease predictors and successful clinical trials of a novel therapeutic modality.