Search ©2012 CRRT Inc. CRRT 2012 Conference - Program and Workshops CRRT 2012 Final Program Monday, February 13 5:00-8:00pm Conference Registration Open Pre-Conference AKI Workshop Tuesday, February 14 7:00am Conference and Workshop Registration Open 8:00-5:30 PW1 Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management sponsored by: The UAB-UCSD O’Brien Core Center for Kidney Injury Research Conference registration is not required to attend this elective workshop. Acute Kidney Injury is a rapidly evolving area where several advances have been made in understanding the mechanisms and pathways of AKI and its effects on other organs. Recent identification of biomarkers has provided new tools and techniques to characterize this disorder, This pre-course workshop will provide a comprehensive review of the most recent developments in the field and describe emerging knowledge from basic and translational research. Results from clinical trials will be discussed to define the best strategies for effective management of patients and define the criteria for future studies. 7:55-8:00 Opening Remarks Ravindra L. Mehta, MBBS, MD, DM, FACP AKI Workshop - Plenary 1 Molecules, Mechanisms and Targets 8:00-10:00 Co-chair: Anupam Agarwal, MD Co-chair: Bruce A. Molitoris, MD 8:00-8:20 The Pathogenesis of Acute Kidney Injury (AKI) & the Toxic Triangle of O2, NO & ROS Can Ince, PhD 8:20-8:40 Mitochondria Dynamics in AKI Zheng Dong, PhD 8:40-9:00 Sepsis and AKI: What Have We Learned? Martin Matejovic, MD 9:00-9:20 Cell Cycle Regulation in AKI Robert Safirstein, MD 9:20-9:40 Is Renal Dysfunction of Cirrhosis Truly Reversible? Rajiv Jalan, MD, PhD 9:40-10:00 Mechanisms of Repair After AKI Ben Humphreys, MD, PhD 10:00-10:15 Coffee Break AKI Workshop - Plenary 2 Translational Research: Bedside to Bench and Back 10:15-12:15 Co-chair: John A. Kellum, MD Co-chair: Robert Schrier, MD 10:15-10:35 Immune Hyporesponsiveness: Target for Monitoring and Intervention? Didier Payen, MD 10:35-10:55 Human Endotoxemia: Does it Lead to Tubular Injury? Peter Pickkers, MD, PhD 10:55-11:15 Acute Kidney Injury in Sepsis: A Role of the Microcirculation? Daniel De Backer, MD 11:15-11:35 Targeting Nrf2 Regulation of Oxidative Stress to Improve AKI Hamid Rabb, MD 11:35-11:55 Targeting Recovery: What?s Needed? Ravindra L. Mehta, MBBS, MD, DM, FACP 11:55-12:15 Utilizing Mechanistic Modeling to Facilitate Clinical Drug Development William L. Macias, MD, PhD 12:15-1:15 Lunch Hosted by Conference for Workshop Participants AKI Workshop - Concurrent Session A Plenary 3 - Pre-Clinical Models for Translational Research in AKI 1:15-3:15 Co-chair: Roland C. Blantz, MD Co-chair: Paul Sanders, MD 1:15-1:35 Rodent Models and Imaging Kurt Zinn, DVM, PhD 1:35-1:55 Dissecting Immune Responses in AKI Mark D. Okusa, MD 1:55-2:15 Unraveling the Interactions of AKI and CKD Roland C. Blantz, MD 2:15-2:35 Visualizing the Microcirculation Bruce A. Molitoris, MD 2:35-2:55 Using Gene-targeted Mice to Study Renal Physiology In Vivo Volker Vallon, MD 2:55-3:15 Genetic Labeling Techniques Ben Humphreys, MD, PhD 3:15-3:30 Coffee Break AKI Workshop - Plenary 3, Concurrent Session B Enhancing Clinical and Translational Research in AKI 1:15-3:15 Co-chair: Claudio Ronco, MD Co-chair: Robert Safirstein, MD 1:15-1:35 When Did AKI Start: Baseline vs Reference Creatinine Etienne Macedo, MD, PhD 1:35-1:55 Clinical Endpoints for AKI: Do We Have a Consensus? John A. Kellum, MD 1:55-2:15 Outcomes Research: The Role of an AKI Registry Josée Bouchard, MD 2:15-2:35 Design Issues and Strategies for Biomarker Guided Clinical Trials Zoltan Endre, MD, PhD 2:35-2:55 Post-Cardiac Arrest Therapeutic Hypothermia and Acute Kidney Injury Henry Wang, MD, MS 2:55-3:15 Trial Designs for Preventing AKI Progression to CKD Lakhmir S. Chawla, MD 3:15-3:30 Coffee Break AKI Workshop - Plenary 4, Concurrent Session A Techniques for Clinical Research in AKI 3:30-5:30 Co-chair: Mark D. Okusa, MD Co-chair: Hamid Rabb, MD 3:30-3:50 Epigenetics and the Interface Between Host and Environment Andrew D. Shaw, MD FRCA 3:50-4:10 Diagnostic Value of Urine Electrolytes in AKI Robert Schrier, MD 4:10-4:30 Candidate Biomarkers for Sepsis Associated AKI in Children: A Microarray Analysis Hector Wong, MD 4:30-4:50 Biomarkers in AKI: An Update Jonathan Barasch, MD PhD Kai Schmidt-Ott, MD 4:50-5:10 Assessing Kidney Function in the Patient with Cardiorenal Syndrome Claudio Ronco, MD 5:10-5:30 Urinary Exosomes: Emerging Tools for Characterizing AKI Pam Taub, MD 5:30pm AKI Workshop Adjourns HW1 Fundamentals of CRRT Tuesday, February 14 HW1 Fundamentals of CRRT This workshop offers an introduction to CRRT techniques and is developed to provide a core set of information on the principles and practice of CRRT. This workshop will cover the components and basic principles of continuous renal replacement therapy. The operating characteristics of CRRT techniques for solute and fluid management, drug management will be discussed along with the potential applications of these techniques. Requirements for developing a successful CRRT program and selecting machines will also be described. Full Day Concurrent Workshop - HW1 8:00-5:30 7:55-8:00 Fundamentals of CRRT - Opening Remarks Jorge Cerda, MD, FACP, FASN Ashita Tolwani, MD 8:00-8:30 Operating Principles of CRRT William R. Clark, MD 8:30-9:00 Access/Membrane and Circuit Luis Juncos, MD 9:00-9:30 Anticoagulation Ashita Tolwani, MD 9:30-10:00 Solute Control and Dose Rolando Claure, MD 10:00-10:15 Discussion 10:15-10:30 Coffee Break 10:30-11:00 Solutions Ashita Tolwani, MD 11:00-11:30 Fluid Management Ravindra L. Mehta, MBBS, MD, DM, FACP 11:30-12:00 Drug Management Jeffrey Lipman, MD 11:45-12:10 Patient Selections and Outcomes Jorge Cerda, MD, FACP, FASN 12:10-12:30 Discussion 12:30-1:15 Lunch Hosted by Conference for Workshop Participants 1:15-1:45 Organizational and Financial Aspects Jorge Cerda, MD, FACP, FASN 1:45-2:15 Pharmacy Support Linda Awdishu, PharmD, MAS 2:15-2:45 Nursing Issues Eileen Lischer, MA, BSN, RN, CNN 2:45-3:15 Nutritional Support Miet Schetz, MD, PhD 3:15-3:30 Coffee Break 3:30-4:00 Discussion 3:45-4:00 Monitoring and Preventing Complications Javier Maynar, MD 4:00-4:30 CRRT Outcome Studies Sean Bagshaw, MD, MSc, FRCPC 4:30-5:00 Available Technology Noel Gibney, MB FRCP(C) 5:30pm Adjourn Tuesday, February 14 HW2 Half Day Workshop Half Day Concurrent Workshop-HW2 8:00-12:30 8:00-12:30 HW2 Gambro Physician's Hand-On Workshop Practical CRRT - The Nuts and Bolts Luis Alvarez, MD, PhD Through case studies, lecture and Prismaflex System hands-on practice, this workshop will provide practical approaches to prescribing and delivering CRRT with Gambro?s leading CRRT system. CME Credits Do Not Apply 10:15-10:30 Coffee Break 10:30-12:30 Gambro Physician's Hand-On Workshop (continued) 12:30-1:15 Lunch Hosted by Conference for Workshop Participants Tuesday, February 14 Standard Workshops Open to all participants and applicable to physicians, nurses and allied personnel. (Codes: C= Core workshop, I = Intermediate, A = Advanced, N= Nurses, AP = of interest to nurses and allied personnel) Workshops designated by an asterisk (*) will be presented twice in different time slots. Workshops presented in a series are marked with a ""1"" for a primary workshop discussion in this area and "2" for a more complex or advanced discussion in this area. Please note that the series workshops 1 and 2 can be either taken subsequently (following each other) or they can each be taken independently (e.g. workshop 1 can be taken without taking workshop 2 and vice versa). Workshop Group 1 4:00-5:30 4:00-5:30 A01 Assessing the Microcirculation (C, N, AP) Rolando Claure, MD Can Ince, PhD Etienne Macedo, MD, PhD Techniques of monitoring and interpretation of microcirculatory alterations in critical illness as measured by direct sublingual observation. Strategies to assess microcirculatory alterations in the critically ill patients will be presented and discussed. 4:00-5:30 B02 Plasma Exchange Therapy and Hybrid Techniques (C, N, AP) Hiroyuki Hirasawa, MD David M. Ward, MD, FRCP Principles of catheter choice, Principles of plasma exchange, sorbent based and hybrid therapies for extracorporeal support. Case based discussion of practical application of plasma exchange, sorbent based and hybrid therapies for extracorporeal support. 4:00-5:30 C03 Critical Care Pharmacology: Vasopressors, and Inotropes (A, N, AP) Jeffrey Lipman, MD Peter Pickkers, MD, PhD Pathophysiology of shock and the principles and practical use of vasopressors, ionotropes, vasodilators in critically ill patients. 4:00-5:30 D04 Biomarkers 1: Principles and Applications (C, N, AP) Zoltan Endre, MD, PhD William L. Macias, MD, PhD Principles and classification of biomarkers and their application for diagnosis and management of diseases. Criteria for using biomarkers as surrogate end points. 4:00-5:30 E05 Liver and the Kidney 1: Principles of Hepatic Dysfunction (A, N) Rajiv Jalan, MD, PhD Heather Patton, MD Pathophysiology of hepatic failure and rationale for use of different techniques for 4:00-5:30 F06 Competency Assessment in CRRT (C, N) Patty Graham, RN, MS, CCRN, CS Eileen Lischer, MA, BSN, RN, CNN Description on training requirements, core curriculum and skills assessment for CRRT care delivery. 4:00-5:30 G07 Fluids and Solutions in the Critically Ill 1 (A) Daniel De Backer, MD Andrew D. Shaw, MD FRCA How to select and use colloids, crystalloids and blood products. 4:00-5:30 H08 Preventing and Managing Complications of Dialysis 1: Intradialytic Hypotension (C, N) Andrew Davenport, MD, FRCP Nick Selby, MD Definitions and pathophysiology of intradialytic hypotension. Strategies for prevention and management. 4:00-5:30 I01 CRRT Systems I* I. B. Braun - CRRT Systems (C, N, AP) Device demonstrations of features, setup, operation, monitoring and discontinuation 6:00-7:30pm Reception and Poster Review Wednesday Morning, February 15 7:00-4:30pm Conference Registration Open 7:00-8:15 ME1 MEET THE EXPERT-Session 1 Daniel De Backer, MD Hiroyuki Hirasawa, MD 7:00-8:15 ME2 MEET THE EXPERT-Session 2 Rajiv Jalan, MD, PhD Robert Schrier, MD Workshop Group 2 8:15-9:45 8:15-9:45 A09 Vascular Access /Membrane and Circuit (C, N, AP) Luis Juncos, MD Emil P. Paganini, MD, FACP, FRCP Principles of catheter choice, placement, maintenance, recognition and management of complications, selection and use of membranes for different applications, circuit design, setup and monitoring 8:15-9:45 B10 Dialysis Dose Prescription and Delivery (C, N, AP) William R. Clark, MD Rolando Claure, MD Claudio Ronco, MD Operational characteristics influencing solute removal in CRRT 8:15-9:45 C11 Critical Care Management: Nutrition Assessment and Delivery (I, N, AP) Oliver Joannes-Boyau, MD Miet Schetz, MD, PhD Pathophysiology of malnutrition in critically ill patients. Principles of nutritional assessment and support and adjustments for RRT. 8:15-9:45 D12 Biomarkers 2: Application in AKI (I, N, AP) Josée Bouchard, MD Dinna Cruz, MD, MPH Zoltan Endre, MD, PhD Development and qualification of structural and functional biomarkers for AKI. Current performance characteristics and application for diagnosis, management and prognostication in AKI. 8:15-9:45 E13 Liver and the Kidney 2: Principles of Extracorporeal Hepatic Support (A, N) Andrew Davenport, MD, FRCP Rajiv Jalan, MD, PhD Pathophysiology of hepatic failure and rationale for use of different techniques for extracorporeal support techniques (Cell based systems, MARS, CRRT) for hepatic support. 8:15-9:45 F14 Therapeutic Modalities: IHD, SLED, PD (C, N, AP) Emmanuel Burdmann, MD, PhD Thomas A. Golper, MD Vishnu Bhotla Sivakumar, MD, DM, DNB, FISN, FR Comparisons of operational characteristics including anticoagulation, membranes, solutions and flows and approaches for ongoing and future research 8:15-9:45 G15 Fluids and Solutions in the Critically Ill 2: Solutions for CRRT (C, N, AP) Linda Awdishu, PharmD, MAS Sean Bagshaw, MD, MSc, FRCPC Solutions for CRRT: What's available and applications for Electrolyte and Acid Base Balance. 8:15-9:45 H16 Preventing and Managing Complications of Dialysis 2: Operation, Fluids, Electrolytes and Acid Base (C, N) Maureen Craig, MSN, RN, CNN Javier Maynar, MD Nick Selby, MD Definitions and explanation of operation, fluids, electrolytes and acid base. 8:15-9:45 I02 CRRT Systems II* NxStage Medical (C, N, AP) Device demonstrations of features, setup, operation, monitoring and discontinuation. 9:45-10:00 Coffee Break Workshop Group 3 10:00-11:30 10:00-11:30 A17 Anticoagulation: Mechanisms and Techniques (C, N, AP) Emmanuel Burdmann, MD, PhD Oliver Joannes-Boyau, MD Ashita Tolwani, MD Anticoagulation regimens: Mechanisms, selection, prescription, monitoring and implementation 10:00-11:30 B18 Fluid Management (C, N, AP) Ravindra L. Mehta, MBBS, MD, DM, FACP Didier Payen, MD Principles of volume assessment, fluid removal and fluid regulation with different CRRT equipment 10:00-11:30 C19 Acid Base and Electrolyte Problems in the Critically Ill 1 (I) John A. Kellum, MD Mitchell H. Rosner, MD Principles for evaluating and managing acid base and electrolyte problems in critically ill patients using case studies. 10:00-11:30 D20 Extracorporeal Techniques for Sepsis 1: Pathophysiology and Targets (A) Patrick M. Honoré, MD Martin Matejovic, MD Pathophysiology of sepsis and rationale for use of extracorporeal support in treatment of sepsis. Experimental models for high permeability membranes, HVHF, VHVHF and hybrid therapies 10:00-11:30 E21 Heart Failure and Cardio-renal Syndrome 1: Pathophysiology (I) Alan Maisel, MD Claudio Ronco, MD Pathophysiology, recognition and management strategies for cardiac and renal failure in the critically ill patient. 10:00-11:30 F22 Ensuring Patient Safety and Quality Measures for RRT in AKI 1: Water Standards, Infection Control (C, N, AP) Thomas A. Golper, MD Eileen Lischer, MA, BSN, RN, CNN Discussion of the recent developments in ensuring quality and patient safety for acute dialysis delivery. 10:00-11:30 G23 Pediatric CRRT: The Basics (I, N, AP) Geoffrey Fleming, MD Scott Sutherland Jordan M. Symons, MD Michael Zappitelli, MD, MSc Technique requirement and application for use in children excluding neonates. Covering epidemiology of pediatric acute kidney injury, and a focus on the pediatric CRRT prescription (anticoagulation, fluid composition, modality, and nutrition provision), as well as outcome in pediatric CRRT. 10:00-11:30 H24 Patient Centered Care in the ICU: The Team Approach (I, N, AP) Peter Brindley, MD Patty Graham, RN, MS, CCRN, CS Taking good care of patients requires communication and understanding of the needs of patients and their loved ones. This workshop will discuss the principles and practice of patient centered care utilizing case studies. 10:00-11:30 I03 CRRT Systems I* I. B.Braun - CRRT Systems (C, N, AP) Device demonstrations of features, setup, operation, monitoring and discontinuation. (repeat of I01) 11:30-1:00 Luncheons Hosted by Conference (RSVP Required) Selection made during registration Conference Luncheon Nursing Forum Luncheon Peter Brindley, MD Communication in Crisis: Improving Our "Verbal Dexterity" Strong verbal communication skills are essential for establishing a shared mental model, coordinating tasks, centralizing the flow of information, or stabilizing emotions during a medical crisis. This talk will provide a framework for understanding the importance of communication skills, and will share ideas from other high risk industries that have the potential to improve medical team performance and medical safety. Gambro Focus Group Luncheon Looking for an Expert Opinion? Overview of the KDIGO Guideline for AKI Hear an up-to-date expert consensus on AKI treatment with a focus on the evidence-based application of CRRT in the ICU. ALERE Focus Group Luncheon Plasma NGAL Updates: The Cardiorenal Syndrome and Next Generation Assay Speakers will present new information about applications of an extended range plasma NGAL assay including its use for more timely diagnosis in the early phases of the Cardiorenal syndrome, for risk stratification of those at increased risk of short-term adverse heart failure related outcomes and on the utility of a next generation plasma NGAL assay for improved diagnosis in critically ill patients. SESSION I: PATIENT CHARACTERISTICS Plenary 1 MINI-SYMPOSIA Organ Dysfunction in the Critically Ill Patient: Emerging Concepts 1:10-3:45 Co-chair: John A. Kellum, MD Co-chair: Peter Pickkers, MD, PhD 1:10-1:15 Opening Remarks Ravindra L. Mehta, MBBS, MD, DM, FACP 1:15-1:30 Sepsis and AKI: Bidirectional and Synergistic Relationship? Martin Matejovic, MD 1:30-1:45 Metabolic Derangement and Nutritional Support in Sepsis with Organ Failure Hiroyuki Hirasawa, MD 1:45-2:00 Nutritional Support in ICU Patients: Does Timing and Route Matter? Miet Schetz, MD, PhD 2:00-2:15 Microcirculatory Alterations: Potential Mechanisms and Implications for Therapy Daniel De Backer, MD 2:15-2:30 The Endothelial Glycocalyx: A New Target in Critical Illness Can Ince, PhD 2:30-2:45 The Future is Predetermined in Severe Sepsis, So What are the Implications? Didier Payen, MD 2:45-3:00 Tailored Therapeutics and Personalized Medicine: Is it Possible in Critical Illness? William L. Macias, MD, PhD 3:00-3:25 SPECIAL LECTURE Engineering Critical Care Medicine: A New Way to Protect Our Patients Peter Brindley, MD 3:25-3:45 Panel Discussion 3:45-4:15 Coffee Break Plenary 2 MINI-SYMPOSIA Acute Kidney Injury (AKI): Pathophysiology 4:15-6:30 Co-chair: Stuart L. Goldstein, MD Co-chair: Kazo Kaizu, MD 4:15-4:30 Minimizing the Renal Toxicity of Iodinated Contrast Peter A. McCullough, MD, MPH 4:30-4:45 AKI in the Patient with Cancer: What Have We Learned? Ben Humphreys, MD, PhD 4:45-5:00 Genome-wide Association Studies (GWAS): Can We Apply to AKI? Robert Safirstein, MD 5:00-5:15 Marrying the Heart and Kidney with Biomarkers: Improved Understanding of the Cardio Renal Syndrome? Alan Maisel, MD 5:15-5:30 Distant Organ Responses in AKI Hamid Rabb, MD 5:30-5:45 Liver-Kidney Interactions in Hepatorenal Syndrome: Who's to Blame? The Kidney The Liver Rajiv Jalan, MD, PhD Robert Schrier, MD 5:45-6:00 Panel Discussion 6:00-6:30 SPECIAL SESSION Critical Care Nephrology Jeopardy Nephrologists vs Intensivists Noel Gibney, MB FRCP(C) 6:30 Adjourn 6:30-8:00 Exhibit Reception and Poster Session Thursday Morning, February 16 7:00am-4:30pm Registration Open 7:00-8:00 Continental Breakfast 7:00-8:00 ME3 MEET THE EXPERT-Session 1 John A. Kellum, MD Peter A. McCullough, MD, MPH 7:00-8:00 ME4 MEET THE EXPERT-Session 2 Didier Payen, MD Claudio Ronco, MD Workshop Group 4 8:00-9:30 8:00-9:30 A25 Drug Management in CRRT (C, N, AP) Jeffrey Lipman, MD Bruce A. Mueller, PharmD, FCCP, FASN Drug Dosing principles for critically ill patients and adjustments in extracorporeal support techniques. 8:00-9:30 B26 Starting and Stopping RRT for AKI: Principles and Practice (A) Etienne Macedo, MD, PhD Ravindra L. Mehta, MBBS, MD, DM, FACP Principles of determining when to start and stop RRT. Case based discussion of various approaches. 8:00-9:30 C27 Acid Base and Electrolyte Problems in the Critically Ill 2 (A, N) Andrew Lewington, MD Mitchell H. Rosner, MD Principles for evaluating and managing acid base and electrolyte problems in critically ill patients using case studies. 8:00-9:30 D28 Extracorporeal Techniques for Sepsis 2 (A) Hiroyuki Hirasawa, MD Patrick M. Honoré, MD Oliver Joannes-Boyau, MD Technical considerations and practical application of extracorporeal support techniques for sepsis. Results of human studies for use of high permeability membranes, HVHF, VHVHF and hybrid techniques for sepsis. 8:00-9:30 E29 Heart Failure and Cardio-Renal Syndrome 2: Management Strategies and Case Studies (I, N, AP) Eric Adler, MD Dinna Cruz, MD, MPH Emil P. Paganini, MD, FACP, FRCP Technical considerations, practical application and results of different methods to treat heart failure and cardio-renal syndrome 8:00-9:30 F30 Ensuring Patient Safety and Quality Measures for RRT in AKI 2: Dialysis Adequacy, Monitoring, Nursing Issues (C, N, AP) Eileen Lischer, MA, BSN, RN, CNN Javier Maynar, MD Ashita Tolwani, MD Discussion of the principles of a systems based approach to implementing and monitoring quality to reduce errors in therapy prescription and delivery. 8:00-9:30 G31 CRRT in the Newborn: Principles and Practical Issues (C, N, AP) David Askenazi, MD Jordan M. Symons, MD Pathophysiology and management of metabolic disorders, neonatal AKI and intoxications with CRRT. 8:00-9:30 H32 Withdrawing & Withholding Support for AKI: Ethical Issues in the ICU (I, N, AP) Rolando Claure, MD Benjamin Freda, DO Noel Gibney, MB FRCP(C) Factors influencing decisions for withholding and withdrawing dialysis in the management of critically ill patients. General principles for ethical decisions and how an approach can be developed to manage patients requiring dialysis. 8:00-9:30 I04 CRRT Systems II NxStage Medical (C, N, AP) Device demonstrations of features, setup, operation, monitoring and discontinuation. (repeat of I02) 9:30-9:45 Coffee Break SESSION II: EMERGING CONCEPTS IN AKI AND CRITICAL CARE Plenary 3 MINI-SYMPOSIA Controversies in Management of the Critically Ill Patient: Fluid Management 9:45-12:40 Co-chair: Hamid Rabb, MD 9:45-10:00 Do Vasoactive Drugs and Fluids Improve Renal Perfusion? Daniel De Backer, MD 10:00-10:15 Saline is Really Bad for You. Hard to Believe. Impossible to Ignore! John A. Kellum, MD 10:15-10:30 What Blood Pressure Should We Target for Patients with AKI? Ravindra L. Mehta, MBBS, MD, DM, FACP 10:30-10:45 What We Do in the OR When You're Not Looking! Andrew D. Shaw, MD FRCA 10:45-11:00 Water, Water, Everywhere: Sodium and Water Balance and the Injured Brain Didier Payen, MD 11:00-11:15 Blood Transfusions are Important for the Resuscitation of the Critically Ill Patient Can Ince, PhD 11:15-11:30 Fluid Management in the Critically Ill: The "5B" Approach Claudio Ronco, MD 11:30-11:45 Thinking Outside of the Box: A Novel Strategy to Prevent Shock Induced AKI Todd Costantini, MD 11:45-12:10 SPECIAL LECTURE Fluid Management in the Critically Ill: Is the Kidney at Risk? Robert Schrier, MD 12:10-12:30 Panel Discussion Noel Gibney, MB FRCP(C) 12:30-12:40 Top Abstract Awards 12:40-2:00 Lunches Hosted by Conference 12:40-2:00 Luncheons Hosted by Conference (RSVP Required) Selection made during registration Conference Luncheon Industry Forum Luncheon Emil P. Paganini, MD, FACP, FRCP Regulatory Requirements for Dialysate/Infusate Solutions for CRRT Several new solutions are now available for CRRT however they are subject to regulatory requirements that often influence the their utilization and introduction in the market. This session will explore the key factors that detremine regulatory approval of solutions for CRRT. Nursing Forum 2 Luncheon Maureen Craig, MSN, RN, CNN Eileen Lischer, MA, BSN, RN, CNN Benchmarking for CRRT: Which Parameters Should We Use? This session will explore the quality measures that should be implemented to assess the delivery of CRRT and for comparisons across centers. "Late Breaking Trials" Luncheon 0 Jonathan Barasch, MD PhD Kai Schmidt-Ott, MD James A. Tumlin, MD AKI, Critical Care, Sepsis and Extracorporeal Support Therapies This session provides results from recent and ongoing clinical trials in AKI, Critical Care, Sepsis and Extracorporeal support therapies to inform participants of the latest research findings in the field. Diagnostic and Prognostic Stratification in the Emergency Department Using Biomarkers of Intrinsic Acute Kidney Injury (AKI) Jonathan Barasch, Kai Schmidt-Ott , MD A Multi-Center Pilot Study to Assess the Safety and Efficacy of Selective Cytopheretic Device (SCD) Therapy in Patients with Acute Kidney Injury (AKI) James Tumlin, MD Gambro Focus Group Luncheon Getting the MOST out of Your CRRT System Learn how new options with the Prismaflex System are creating opportunities to provide your patients with Multi-Organ Support Therapy. SESSION II: EMERGING CONCEPTS IN AKI AND CRITICAL CARE Plenary 4 MINI SYMPOSIA Advancing Clinical Care and Research in AKI; the Role of Biomarkers: Report from the 10th ADQI Conference, Dublin, Ireland, August 2011 2:00-3:30 Co-chair: Josée Bouchard, MD Co-chair: Bruce A. Molitoris, MD 2:00-2:15 Biomarkers in AKI: Current Status and Needs Lakhmir S. Chawla, MD 2:15-2:30 Diagnosis of AKI: Can We Improve Recognition with Biomarkers? Claudio Ronco, MD 2:30-2:45 Differential Diagnosis of AKI: Can Biomarkers Help? Zoltan Endre, MD, PhD 2:45-3:00 Use of Biomarkers to Assess Prognosis and Guide Management of AKI Dinna Cruz, MD, MPH 3:00-3:15 Physiological and Imaging Markers of AKI Mark D. Okusa, MD 3:15-3:30 Looking to the Future: Biomarker Enhanced Decision Support for AKI Management Ravindra L. Mehta, MBBS, MD, DM, FACP 3:30-4:00 Coffee Break Plenary 5 MINI SYMPOSIA Challenges and Controversies in Renal Support and CRRT 4:00-6:00 Co-chair: Emmanuel Burdmann, MD, PhD Co-chair: Jorge Cerda, MD, FACP, FASN 4:00-4:15 Myocardial Stunning and Brain Edema: Acute Effects of Dialysis Nick Selby, MD 4:15-4:30 Therapeutic Drug Monitoring During Dialysis Support Jeffrey Lipman, MD 4:30-4:45 Cutting it Short: Implications of Drug Shortages in the ICU Linda Awdishu, PharmD, MAS 4:45-5:00 CRRT and ECMO: Techniques and Outcomes from the ELSO Registry David Askenazi, MD 5:00-5:15 Comparing RRT Modalities: Does it Matter What You Use if the Job is Done? Sean Bagshaw, MD, MSc, FRCPC 5:15-5:30 Management of Severe Heart Failure: A Role for Ultrafiltration? Eric Adler, MD 5:30-5:45 Telemedicine in the ICU: The Future is Here Jeffrey Lipman, MD 5:45-6:00 Avoiding Anticoagulation for CRRT: An Update on Emerging Membranes Patrick M. Honoré, MD 6:00 Adjourn Free Evening Friday Morning, February 17 7:00-5:00 Conference Registration Open 6:30-7:30 Continental Breakfast SESSION III: TECHNIQUE CHARACTERISTICS Plenary 6 MINI SYMPOSIA Emerging Concepts in AKI 7:30-10:00 Co-chair: Lakhmir S. Chawla, MD Co-chair: Oliver Joannes-Boyau, MD 7:30-7:45 Rediscovering Urine Electrolytes for Differential Diagnosis and Prognosis of AKI Etienne Macedo, MD, PhD 7:45-8:00 Measuring GFR on Demand: Ready for Prime Time? Bruce A. Molitoris, MD 8:00-8:15 Improving Outcomes from AKI: Lessons from the UK? Andrew Lewington, MD 8:15-8:30 Combined CRRT-bilibrubin Adsorption System for Liver Failure 0 Zhi-Hong Liu, MD 8:30-9:30 The Changing Face of AKI: Snapshots from Around the World Brazil, India, Japan, Canada, Australia, USA Sean Bagshaw, MD, MSc, FRCPC Emmanuel Burdmann, MD, PhD Zoltan Endre, MD, PhD Stuart L. Goldstein, MD Kazo Kaizu, MD Vishnu Bhotla Sivakumar, MD, DM, DNB, FISN, FR 9:30-9:45 Alkaline Phosphatase Peter Pickkers, MD, PhD 9:45-10:00 Recent Trials in the Prevention of Contrast-Induced AKI: Importance of Emerging Biomarkers Peter A. McCullough, MD, MPH 10:00-10:30 Coffee Break SESSION IV: FUTURE TRENDS IN CRRT AND CRITICAL CARE Plenary 7 MINI SYMPOSIA Emerging Strategies in AKI and Extracorporeal Support 10:30-1:00 Co-chair: Zhi-Hong Liu, MD Co-chair: Bruce A. Mueller, PharmD, FCCP, FASN 10:30-10:55 SPECIAL LECTURE When Enough Is Enough: The Nephrologist's Responsibility in Ordering Dialysis Treatments Benjamin Freda, DO 10:55-11:10 Cytokine Modulation in Sepsis: Results with the PMMA-CHDF Technique Hiroyuki Hirasawa, MD 11:10-11:25 Ultrasound Techniques in Nephrology: Application in AKI Kianoush Kashani, MD 11:25-11:40 Simulation: Success or Failure Within Ten Years Peter Brindley, MD 11:40-11:55 Surveillance and Early Recognition of AKI: Does it Make a Difference? Nick Selby, MD 11:55-12:10 Preventing Traumatic Brain Injury Induced Blood Brain Barrier Permeability: Novel Future Therapies Vishal Bansal, MD, FACS 12:10-12:25 Thrombocytopenia Associated Multi-Organ Failure (TAMOF): Results from the Multi-center Pediatric Plasmapheresis Trial James Fortenberry, MD, FCCM, FAAP 12:25-12:55 Critical Care Nephrology: Literature Review Noel Gibney, MB FRCP(C) 12:55-1:00 Closing Remarks Ravindra L. Mehta, MBBS, MD, DM, FACP 1:00 Conference Adjourns Friday Afternoon, February 17 2:00-5:30 CONCURRENT ELECTIVE WORKSHOPS 1:00-2:00 Lunch Hosted by Conference for Workshop Participants Concurrent Elective Workshops Session 1 2:00-5:30 2:00-5:30 HW3 Pediatric Hands-On Workshop Steven R. Alexander, MD< Amelia Allsteadt, BSN,RN,CNN Helen Currier, BSN, RN, CNN, CENP Geoffrey Fleming, MD Jolyn Kleinholz, RN Alisa Palazzolo, BSN, RN This workshop will focus upon the practical aspects of care including clinical program development, discussion of various models of ICU and Nephrology medical nursing care and hands on machine setup and operation. 2:00-5:30 HW4 Hemodynamic Monitoring and Use of Drugs Lakhmir S. Chawla, MD Can Ince, PhD Andrew D. Shaw, MD FRCA Critically ill Patients require frequent assessments and monitoring of hemodynamic and respiratory parameters to optimize stability and guide ventilator support. Several techniques are now available and utilized to manage patients including devices to assess the microcirculation, volume responsiveness and cardiac performance. This workshop will cover the principles and strategies for hemodynamic and microcirculatory monitoring and ventilator management in critically ill patients. 2:00-5:30 HW5 Essentials for Developing, Nurturing and Growing a CRRT Program Jorge Cerda, MD, FACP, FASN Patty Graham, RN, MS, CCRN, CS Eileen Lischer, MA, BSN, RN, CNN Bruce A. Mueller, PharmD, FCCP, FASN Successful CRRT programs require careful planning, nurturing and ongoing monitoring for growth and effectiveness.. This workshop will cover the key elements for building and enhancing a program. Topics to be covered include developing a multidisciplinary team, creating tool kits for training, assessments and monitoring effectiveness of the program, dealing with administration, financial considerations and strategies for program growth. 2:00-5:30 HW6 Introduction to Critical Care Ultrasonography Charanjit Bahniwal, MD Daniel De Backer, MD Shyamala Karuvannur, MD Kianoush Kashani, MD Edwin Lee, MD Navparkash Sandhu, MD CCUS or critical care ultrasonography is a Ultrasonography examination performed and interpreted by intensivist at the bedside, to establish the diagnosis and guides procedures, locate a target organ or a disease specific condition. It serves as a complement to CXR,CT,MRI, Echo, or other imaging modalities. This introductory CCUS workshop is a four hour workshop that includes one hour introductory lecture, one hour reviewing normal and abnormal images, and two hours hands on session. The components of this workshop are: abdominal (kidney, bladder, IVC and aorta); thoracic( lung and pleural space); vascular (vascular access and DVT). 2:00-3:15 Session 1 3:15-3:30 Coffee Break 3:30-5:30 Session 2 5:30 Workshops Adjourn