Search © 2013 CRRT Inc. CRRT 2014 Conference - Program and Workshops Complete CRRT Brochure PDF (988K) Monday, March 3 5:00-8:00pm Conference Registration Open Half Day Industry Workshop - IND1 1:30-5:30 1:30-5:30 IND1 Gambro Physician's Hand-On Workshop Practical CRRT - The Nuts and Bolts Luis Alvarez, MD, PhD Through Case studies, lecture and Prismaflex System hands-on practice, this workshop will provide practical approaches to prescribing and delivering CRRT with Gambro's leading CRRT system.CME Credits Do Not Apply Tuesday, March 4 Pre-Conference AKI Symposium 7:00am Conference and Workshop Registration Open 8:00-5:30 PW1 Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management sponsored by: The UAB-UCSD O'Brien Core Center for Kidney Injury Research Acute Kidney Injury is a rapidly evolving area where several advances have been made in understanding the mechanisms and pathways of AKI and its effects on other organs. Recent identification of biomarkers has provided new tools and techniques to characterize this disorder. This pre-course workshop will provide a comprehensive review of the most recent developments in the field and describe emerging knowledge from basic and translational research. Results from clinical trials will be discussed to define the best strategies for effective management of patients and define the criteria for future studies. CRRT Conference registration is not required to attend this symposium, separate registration is available. 7:55-8:00 Opening Remarks Ravindra L. Mehta, MBBS, MD, DM, FACP, AKI Symposium - Plenary 1 Molecules, Mechanisms and Targets 8:00-10:00 Co-chair: Anupam Agarwal, MD Co-chair: Bruce A. Molitoris, MD 8:00-8:10 Session Introduction Anupam Agarwal, MD 8:10-8:30 PW1 Intracellular Pattern Recognition Receptors and Renal Ischemia Dianne McKay, Professor 8:30-8:50 PW1 Inflammation, Hypoxemia, Nitric Oxide and ROS Conspire to Injure the Kidney Can Ince, PhD 8:50-9:10 PW1 Pyruvic Acid: At the "Cross Roads" of Cellular Energetics, Inflammation, and Cytoresistance Richard Zager, MD 9:10-9:30 PW1 Tubular Changes in the Early Diabetic Kidney-Affecting the Susceptibility to AKI? Volker Vallon, MD 9:30-9:50 PW1 Bacterial Colonization Influences Outcome from AKI Hamid Rabb, MD 9:50-10:00 Session Summary Bruce A. Molitoris, MD 10:00-10:15 Coffee Break AKI Symposium - Plenary 2 Of Mice and Men: Translational Research in AKI 10:15-12:15 Co-chair: Mark D. Okusa, MD Co-chair: Paul Sanders, MD 10:15-10:25 Session Introduction Paul Sanders, MD 10:25-10:45 PW1 Individualizing the Response to Injury: Epigenetics of AKI Daniel O'Connor, MD 10:45-11:05 PW1 Hemolytic Uremic Syndrome: An Evolving Disease Giuseppe Remuzzi, MD 11:05-11:25 PW1 Attenuating the Immune Response in AKI: The Role of Alkaline Phosphatase Peter Pickkers, MD, PhD 11:25-11:45 PW1 Renal Hemodynamics and Oxygenation in Sepsis-associated AKI Prabhleen Singh, MD 11:45-12:05 PW1 Novel Models of AKI: Lessons from Leptospirosis Joe Vinetz, MD 12:05-12:15 Session Summary Mark D. Okusa, MD 12:15-1:15 Lunch Hosted by Conference for Workshop Participants AKI Symposium - Plenary 3 Improving Outcomes in AKI: What Should We Focus On? 1:15-3:15 Co-chair: Lakhmir S. Chawla, MD Co-chair: Paul Palevsky, MD 1:15-1:25 Session Introduction Lakhmir S. Chawla, MD 1:25-1:45 PW1 Clinical Course Following AKI: Recovery vs Progression Chris McIntyre, MD 1:45-2:05 PW1 Harmonizing Care Management in AKI Glenn Chertow, MD 2:05-2:25 PW1 Focus on lipids: HDL and Its Associated Lipoproteins in Cardiac and Renal Disease Peter A. McCullough, MD, MPH 2:25-2:45 PW1 Innovations in Dialysis Care and Delivery Claudio Ronco, MD 2:45-3:05 PW1 Remodeling the Kidney: The Plasticity of Progenitor and Kidney Cells Giuseppe Remuzzi, MD 3:05-3:15 Session Summary Paul Palevsky, MD 3:15-3:30 Coffee Break AKI Symposium - Plenary 4 4 Biomarkers in AKI: Are We Ready for Prime Time? 3:30-5:30 Co-chair: Prasad Devarajan, MD Co-chair: Patrick T. Murray, MD 3:30-3:40 Session Introduction Prasad Devarajan, MD 3:40-4:00 PW1 AKI Biomarkers: Barriers and Solutions Zoltan Endre, MD, PhD 4:00-4:20 PW1 Repair or Progression after AKI: The Role of Biomarkers John A. Kellum, MD 4:20-4:40 PW1 Peri-operative Urinary Biomarkers and its Association with Short and Long Term Mortality Chirag Parikh, MD, PhD 4:40-5:00 PW1 The Kidney in Liver Disease: Can Biomarkers Help? Julia Wendon, MD 5:00-5:20 PW1 Biomarkers in the Management of Cardiorenal Syndrome Alan Maisel, MD 5:20-5:30 Session Summary Patrick T. Murray, MD 5:30pm AKI Workshop Adjourns Tuesday, March 4 Practice Based Learning in CRRT: The Science and the Art PW2 - Practice Based Learning in CRRT: The Science and the Art This workshop is designed to provide participants with the knowledge and understanding for decision making for the effective utilization of CRRT to manage critically ill patients. The workshop will utilize case based discussions to illustrate the underlying concepts for application of CRRT. All participants will be provided access to digital media describing the basic concepts of CRRT and will be expected to have reviewed this material prior to the workshop. Delegates will participate in group exercises to apply their learning for the management of complex cases. At the end of this workshop participants will have an improved understanding of how to utilize CRRT for optimizing renal support. A quiz will be administered pre-and post- course for assessment. The participants will be divided into two teams, one led by Dr. Tolwani and one led by Dr. Cerda. The participants will go through three interactive case simulations and role-playing with their assigned team in the morning and then will switch to the other team in the afternoon. This allows all participants to participate in each physician-led group and go through a total of 6 scenarios covering all aspects of CRRT. Full Day Concurrent Workshop - PW2 8:00-5:30 Co-chair: Jorge Cerda, MD, FACP, FASN Co-chair: Ashita Tolwani, MD 7:45-8:15 PW2 Opening Remarks and Pre-Test Jorge Cerda, MD, FACP, FASN Ashita Tolwani, MD 8:15-10:15 PW2 Groups 1 & 2 - CASE 1 Peds Component and Q&A David Askenazi, MD Stuart L. Goldstein, MD Luis Juncos, MD Ashita Tolwani, MD Catherine Wells, DNP, ACNP-BC, CNN-NP 10:15-10:30 Coffee Break 10:30-12:00 PW2 Group 1 - CASE 4 Dysnatremia Group 2 - CASE 2 Cirrhosis Linda Awdishu, PharmD, MAS Jorge Cerda, MD, FACP, FASN Noel Gibney, MB FRCP(C) Luis Juncos, MD Bruce A. Mueller, PharmD Catherine Wells, DNP, ACNP-BC, CNN-NP Group 1 is led by Awdishu, Gibney, Juncos & Wells Group 2 is led by Cerda & Mueller 12:00-1:00 Lunch Hosted by Conference for Workshop Participants 1:00-1:40 PW2 Groups 1 & 2 - CASE 3 David Askenazi, MD Stuart L. Goldstein, MD Special applications for CRRT Pediatrics combining CRRT wuth ECMO/plasma exchange. 1:45-3:15 PW2 Group 1 - CASE 2 Cirrhosis Group 2 - CASE 4 Dysnatremia Linda Awdishu, PharmD, MAS Jorge Cerda, MD, FACP, FASN Noel Gibney, MB FRCP(C) Luis Juncos, MD Bruce A. Mueller, PharmD Catherine Wells, DNP, ACNP-BC, CNN-NP Group 1 led by Cerda & Mueller Group 2 led by Awdishu, Gibney, Juncos & Wells 3:15-3:30 Coffee Break 3:30-5:00 PW2 Groups 1 & 2 - CASE 5 Sepsis and Ethical Issues Linda Awdishu, PharmD, MAS Michael Connor, MD Patty Graham, RN, MS, CCRN, CS Eileen Lischer, MA, BSN, RN, CNN Ravindra L. Mehta, MBBS, MD, DM, FACP, Catherine Wells, DNP, ACNP-BC, CNN-NP 5:00-5:30 PW2 Post Course Assessment Test and Wrap-up Jorge Cerda, MD, FACP, FASN Ashita Tolwani, MD 5:30pm Adjourn Tuesday, March 4 Half Day Workshops Tuesday Morning - HW1 and HW2 8:00-12:30 8:00-12:30 HW1 Pediatric Hands-On Workshop Helen Currier, BSN, RN, CNN, CENP Jolyn Morgan, RN II, CDN Theresa Mottes, RN Alisa Palazzolo, BSN, RN II This workshop will focus upon the practical aspects of care including clinical program development, discussion of various models of ICU and Nephrology medical nursing care and hands on machine setup and operation. 8:00-12:30 HW2 Nursing: Ensuring Patient Safety and Quality for RRT in AKI Saima Aslam, MD Ian Baldwin, RN, PhD, ACCCN Josée Bouchard, MD Helen Currier, BSN, RN, CNN, CENP Thomas A. Golper, MD Patty Graham, RN, MS, CCRN, CS Eileen Lischer, MA, BSN, RN, CNN Catherine Wells, DNP, ACNP-BC, CNN-NP Session 1: Water Standards, Infection Control, Regulatory issues, Dialysis Adequacy, Monitoring Discussion of the recent developments in ensuring quality and patient safety for acute dialysis delivery. (Aslam, Golper, Lischer) Session 2: Nursing Issues, Care Delivery Standards Description on training requirements, core curriculum and skills assessment for CRRT care delivery. (Baldwin, Graham, Wells) Session 3: Developing a Quality Assessment and Tracking Program: Resources, Reporting, Benchmarks Discussion of the principles of a systems based approach to implementing and monitoring quality to reduce errors in therapy prescription and delivery. (Bouchard, Golper, Currier) Session 4: Test Your knowledge: Technique Case Scenarios Interactive cases demonstrating the flexibility and adaptiveness of CRRT techniques for dynamic comprehensive renal support. (Baldwin, Golper, Graham, Lischer) Tuesday Afternoon - HW3 and HW4 1:30-5:30 1:30-5:30 HW3 Peritoneal Dialysis Steven R. Alexander, MD Amelia Allsteadt, BSN,RN,CNN Richard Amerling, MD Rajasekara Chakravarthi, MD, DNB (Nephrology) This workshop provides physicians and nurses with the background knowledge, skills, and hands-on training to utilize peritoneal dialysis (PD) for the management of patients with acute kidney injury. The workshop will cover the principles of PD, demonstrate the practical considerations for obtaining PD access, setting up and operating manual and cycler based treatment regimens and techniques for monitoring and management of complications. 1:30-5:30 HW4 Plasma Exchange and Hybrid Techniques Emmett Ratigan, MD Amber Sanchez, MD Danuta Trzebinska, MD David M. Ward, MD, FRCP Principles of plasma exchange, sorbent based and hybrid therapies for extracorporeal support and case based discussion of practical application. Faculty Chairs: David Ward MD, Amber Sanchez MD 1:30 ­ 1:35   Introductory remarks - David Ward MD & Amber Sanchez MD 1:35 ­ 2:15   Overview of apheresis and hybrid techniques - David Ward MD 2:15 ­ 2:30   Case-based example: combined therapies - Emmett Ratigan MD 2:30 ­ 3:05   Sorbent-based and other selective apheresis therapies - Amber Sanchez MD 3:05 ­ 3:15   Q & A - Panel      Coffee break 3:30 ­ 4:05   Hemopurification systems for septic shock - Dinna Cruz MD 4:05 ­ 4:35   Complications of Therapeutic Plasma Exchange (TPE) - Danuta Trzebinska MD 4:35 ­ 4:45   Q & A - Panel      5 minute break 4:50 ­ 5:10   Demonstration of centrifugal TPE system - Odette Ada BSN RN 5:10 ­ 5:30   Demonstration of membrane TPE system - Jhun Marquez BSN RN 6:00-7:30pm Reception and Poster Review For All Conference Attendees Wednesday Morning, March 5 Standard Workshops and Focused Symposia Open to all participants and applicable to physicians, nurses and allied personnel. WORKSHOPS Workshop Codes: C= Core workshop, I = Intermediate, A = Advanced, N= Nurses, AP = of interest to nurses and allied personnel Workshops presented in a series are marked with a 1 for a primary workshop discussion in this area and 2 for a more complex or advanced discussion in this area. Please note that the series workshops 1 and 2 can be either taken subsequently (following each other) or they can each be taken independently (e.g. workshop 1 can be taken without taking workshop 2 and vice versa). FOCUSED SYMPOSIA These focused symposia are offered in 3 categories (3 sessions in each category) on Wednesday and Thursday and run concurrrently with the Standard Workshops. Sessions can be taken as a group (3) or independently. Selections made during online registration process. 7:00-4:30pm Conference Registration Open 7:15-8:15 ME1 MEET THE EXPERT - Breakfast Session How do I Manage Patients with High Risk for AKI in the ICU Kathleen Liu, MD, PhD, MAS Andrew D. Shaw, MB FRCA FCCM FFICM 7:15-8:15 ME2 MEET THE EXPERT - Breakfast Session How do I Assess and Follow Up Patients After an Episode of AKI Glenn Chertow, MD Chris McIntyre, MD Standard Workshop Group 1 8:30-10:00 8:30-10:00 A01 Using Kidney Biomarkers for AKI 1: Risk Assessment, Diagnosis and Staging (C, N, AP) Zoltan Endre, MD, PhD Stuart L. Goldstein, MD Patrick T. Murray, MD Practical issues for use of kidney biomarkers for assessing risk and for early recognition and interventions in AKI. 8:30-10:00 B02 Strategies for Optimizing the CRRT Circuit (C, N, AP) David Askenazi, MD Oliver Joannes-Boyau, MD Luis Juncos, MD Case based discussions on best practices to maintain circuits for CRRT focusing on the Access, Anticoagulation and Monitoring. Citrate anticoagulation 8:30-10:00 C03 Vexing Problems in ICU Patients 1: Acid Base and Electrolyte, Sedation, Resistant Infections, C-diff, the Obese Patient (C, N, AP) Bradley Dixon, MD Miet Schetz, MD, PhD Case based discussions for adjustments in drug dosing, renal support and monitoring of complex ICU patients with comorbidities and drug resistant infections. 8:30-10:00 D04 Managing Patients with AKI and Liver Failure 1: Pathophysiology, Differential Diagnosis, Therapy, Use of RRT, Liver Support, Strategies for Bridge to Transplant (C, N, AP) Geoffrey Fleming, MD Heather Patton, MD Pathophysiology of AKI in setting of acute and chronic hepatic failure and management strategies for differential diagnosis and therapy. 8:30-10:00 E05 Challenges in Critical Care Nephrology Nursing 1: Patient Assessment, Preparation, Therapy and Monitoring (C, N, AP) Ian Baldwin, RN, PhD, ACCCN Helen Currier, BSN, RN, CNN, CENP Patty Graham, RN, MS, CCRN, CS Principles and best practices for nursing assessment, preparation & monitoring of patients undergoing RRT. 8:30-10:00 F06 Renal Support in the ICU with IHD, PIRRT, PD, Hybrid Devices (A) Richard Amerling, MD Emmanuel Burdmann, MD, PhD Rajasekara Chakravarthi, MD, DNB (Nephrology) Comparisons of operational characteristics including anticoagulation, membranes, solutions and flows and approaches for ongoing and future research. 8:30-10:00 G07 Preventing and Managing Complications of Dialysis: Circulatory Stress, Intradialytic Hypotension, Fluid and Electrolytes (C, N) Amelia Allsteadt, BSN,RN,CNN Nitin Kohle, MD Marlies Ostermann, MD Case based discussions of related complications in ICU patients. 8:30-10:00 FS1 Assessment of Fluid Responsiveness, Hemodynamic Monitoring and Targets Can Ince, PhD Kianoush Kashani, MD Monty Mythen, MB BS, FRCA, MD, FFI Session 1 of 3 in Fluid Assessment and Management in Critically Ill (FS1, FS4, FS7) 8:30-10:00 FS2 Methodology Glenn Chertow, MD William L. Macias, MD, PhD Andrew D. Shaw, MB FRCA FCCM FFICM Session 1 of 3 in Economics of Acute Kidney Injury (FS2, FS5, FS8) 8:30-10:00 FS3 Basic and Translational Science Models: Relevant for AKI, Resources, Tools and Techniques Bruce A. Molitoris, MD Paul Sanders, MD Volker Vallon, MD Session 1 of 3 in Research Design and Conduct (FS3, FS6, FS9) 10:00-10:15 Coffee Break Standard Workshop Group 2 10:15-11:45 10:15-11:45 A08 Using Kidney Biomarkers for AKI 2: Differential Diagnosis, Interventions and Prognosis (C, N, AP) Prasad Devarajan, MD Kent Doi, MD Edward Siew, MD Strategies for the effective use of kidney biomarkers for managing patients with AKI to guide interventions and predict outcomes. 10:15-11:45 B09 CRRT for the Experienced User 1 (I, N, AP) William R. Clark, MD Rolando Claure, MD, FASN Claudio Ronco, MD Interactive case based discussions on dose adjustments, monitoring for adequacy, modality changes. 10:15-11:45 C10 Critical Care Management: Nutrition Assessment and Delivery (I, N, AP) Michael Joannidis, MD Peter Pickkers, MD, PhD Pathophysiology of malnutrition in critically ill patients. Principles of nutritional assessment and support and adjustments for RRT. 10:15-11:45 D11 Managing Patients with Sepsis 1 : Pathophysiology, Diagnosis, Assessment, Resuscitation, Drug Management, Techniques for Disease Modification, Organ Support and Renal Protection (C, N, AP) Rajit Basu, MD Patrick M. Honoré, MD, PhD Miet Schetz, MD, PhD Case based discussions on pathophysiology of sepsis, rationale and strategies for fluid and vasopressor use for resuscitation and supportive therapy with the sepsis bundle. 10:15-11:45 E12 Challenges in Critical Care Nephrology Nursing 2: Combined CRRT with ECMO, Pheresis, Sorbents, Operating Room (I, N, AP) Ian Baldwin, RN, PhD, ACCCN Eileen Lischer, MA, BSN, RN, CNN Alisa Palazzolo, BSN, RN II Techniques, applications, monitoring and practical issues for implementation. 10:15-11:45 F13 Pediatric Dialysis Techniques 1: Patient Assessment, Prescription, Dosing, Delivery, Implementation and Monitoring (I, N, AP) Theresa Mottes, RN Scott Sutherland, MD Jordan M. Symons, MD Technique requirement and application for use in children excluding neonates. Covering epidemiology of pediatric acute kidney injury, and a focus on the pediatric CRRT prescription (anticoagulation, fluid composition, modality, and nutrition provision), as well as outcome in pediatric CRRT. 10:15-11:45 G14 Starting and Stopping RRT for AKI: Principles and Practice (A) Etienne Macedo, MD, PhD Ravindra L. Mehta, MBBS, MD, DM, FACP, Principles of determining when to start and stop RRT. Case based discussion of various approaches. 10:15-11:45 FS4 Fluids and Solutions Crystalloids, Colloids and Blood Products: When and How to Use Matthias Jacob, MD John Prowle, MA MSc MD MRCP FFICM Andrew D. Shaw, MB FRCA FCCM FFICM Session 2 of 3 in Fluid Assessment and Management in Critically Ill (FS1, FS4, FS7) 10:15-11:45 FS5 Diagnosis, Prognosis and Therapy Lakhmir S. Chawla, MD John A. Kellum, MD William L. Macias, MD, PhD Session 2 of 3 in Economics of Acute Kidney Injury (FS2, FS5, FS8) 10:15-11:45 FS6 Clinical Research Zoltan Endre, MD, PhD Vivek Jha, MD Chirag Parikh, MD, PhD Session 2 of 3 in Research Design and Conduct (FS3, FS6, FS9) 11:45-1:00 Luncheons Hosted by Conference (RSVP Required) Selection made during registration Conference Luncheon GAMBRO - Symposium Luncheon Long-term Dialysis Dependence after AKI: Health Economic Implications? Dr. Antoine Schneider and Dr. Sean Bagshaw will present recent evidence that the initial RRT modality prescribed for critically ill AKI patients may be associated improved renal recovery. If initial use of CRRT is associated with improved renal recovery, long-term health economics associated with dialysis dependence could be positively affected. Non-CME GRIFOLS - Symposium Luncheon Issues in Fluid Management in the Critical Care Setting Dr. Andrew Shaw and Dr. John Kellum will discuss the spectrum of physiological changes that occur over time in critically ill patients and the physiologic effect of different fluid types that could be administered. The presented concepts will also be discussed in the context of illustrative patient cases. Dr. Lakhmir Chawla will moderate this symposium. Non-CME Wednesday Afternoon, March 5 Opening Session SESSION I: PATIENT CHARACTERISTICS Plenary 1 MINI-SYMPOSIA Organ Dysfunction in the Critically Ill Patient: Emerging Concepts 1:10-3:45 Co-chair: Prasad Devarajan, MD Co-chair: William L. Macias, MD, PhD 1:10-1:15 Opening Remarks Ravindra L. Mehta, MBBS, MD, DM, FACP, 1:15-1:30 Human Adaptations to Hypoxia: Lessons for Critical Illness Monty Mythen, MB BS, FRCA, MD, FFI 1:30-1:45 Prospects for a Vascular Therapy in Sepsis Samir Parikh, MD 1:45-2:00 Pathophysiology of Critical Illness: The Role of Glycocalyx Matthias Jacob, MD 2:00-2:15 Critical Care Normality: Individualized Versus Protocolized Care Julia Wendon, MD 2:15-2:30 Modulating the Human Innate Response: The Iceman Cometh Peter Pickkers, MD, PhD 2:30-2:45 Spleen the Forgotten Organ in Critical Illness Mark D. Okusa, MD 2:45-3:00 Acute Lung injury and ARDS: What's New? Kathleen Liu, MD, PhD, MAS 3:00-3:25 SPECIAL LECTURE ISN "0 by 25" A Human Rights Case for Health Equity: Acute Kidney Failure in Poor Countries Should No Longer be a Death Sentence Giuseppe Remuzzi, MD 3:25-3:45 Panel Discussion 3:45-4:15 Coffee Break Plenary 2 MINI-SYMPOSIA Acute Kidney Injury (AKI): Pathophysiology 4:15-6:30 Co-chair: Chris McIntyre, MD Co-chair: Bruce A. Molitoris, MD 4:15-4:30 Subclinical AKI: A New Entity Claudio Ronco, MD 4:30-4:45 The Rising Tide of AKI - Epidemic or Hype? Edward Siew, MD 4:45-5:00 Consequences of Hypoxia in AKI Kent Doi, MD 5:00-5:15 Community-acquired AKI in Tropical Countries Vivek Jha, MD 5:15-5:30 Atypical HUS and AKI Bradley Dixon, MD 5:30-5:50 The Furosemide Stress Test: A Means to Evaluate Incipient AKI? Lakhmir S. Chawla, MD 5:50-6:00 Panel Discussion 6:00 Adjourn 6:00-7:30 Exhibit Reception and Poster Session Thursday Morning, March 6 7:00am-4:30pm Registration Open 7:00-8:00 Coffee Served 7:15-8:15 ME3 MEET THE EXPERTS - Breakfast Session How I Assess Patients in the ICU and My Approach to Oliguria John A. Kellum, MD Marlies Ostermann, MD 7:15-8:15 ME4 MEET THE EXPERT - Breakfast Session How I Use the KDIGO AKI Guidelines to Manage Patients Paul Palevsky, MD Claudio Ronco, MD Standard Workshop Group 3 8:00-9:30 8:00-9:30 A15 Optimal Care for AKI: The 5 R Approach (C, N, AP) Jorge Cerda, MD, FACP, FASN Stuart L. Goldstein, MD Andrew Lewington, MD This workshop will describe the urgent need for educating care givers, patients and the lay public on the devastating effects of AKI. Strategies and tools for risk assessment, recognition response, rehabilitation and referral for AKI will be discussed. 8:00-9:30 B16 CRRT for the Experienced User 2: Solutions, Fluid Removal Fluid Balance, Monitoring (A) Matthias Jacob, MD Ravindra L. Mehta, MBBS, MD, DM, FACP, John Prowle, MA MSc MD MRCP FFICM Interactive case based discussion on strategies for fluid management in CRRT to achieve patient driven outcomes for fluid, electrolyte and acid base balance. 8:00-9:30 C17 Drug Induced Kidney Injury in the ICU: Mechanisms, Susceptibility, Diagnosis, Management Strategies (A, N) Linda Awdishu, PharmD, MAS Rajit Basu, MD Michael Joannidis, MD Causes and consequences of drug induced nephrotoxicity, factors contributing to toxicity, strategies for preventing and managing toxicity. Utilization of dialysis techniques for drug removal 8:00-9:30 D18 Managing Heart Failure and Cardio-Renal Syndrome: Pathophysiology, Diagnosis, Drug Management, Ultrafiltration, Renal Support and RRT for Patients with Ventricular Assist Devices and Artificial Hearts (A, N) Dinna Cruz, MD, MPH Peter A. McCullough, MD, MPH Technical considerations, practical application and results of different methods to treat heart failure and cardio-renal syndrome including ultrafiltration techniques. 8:00-9:30 E19 Patient Centered Care: Enhancing Communications and Care Delivery (C, N, AP) Steven R. Alexander, MD Patty Graham, RN, MS, CCRN, CS Jolyn Morgan, RN II, CDN Taking good care of patients requires communication and understanding of patient and loved ones' needs. This workshop will discuss the principles and practice of patient centered care utilizing case studies. 8:00-9:30 F20 Pediatric Dialysis Techniques 2: CRRT in the Newborn, ECMO, Combination Therapies, Drug Dosing, Transitions (C, N, AP) David Askenazi, MD Geoffrey Fleming, MD Pathophysiology and management of metabolic disorders, neonatal AKI and intoxications with CRRT. 8:00-9:30 G21 Ethical Issues in the ICU: Withdrawing & Withholding Renal Support for AKI (C, N, AP) Rolando Claure, MD, FASN Noel Gibney, MB FRCP(C) Factors influencing decisions for withholding and withdrawing dialysis in the management of critically ill patients. General principles for ethical decisions and how an approach can be developed to manage patients requiring dialysis. 8:00-9:30 FS7 Vasopressors and Inotropes and Combinations with Fluid Patrick D. Brophy, MD, MHCDS Phil Dellinger, MD Miet Schetz, MD, PhD Session 3 of 3 in Fluid Assessment and Management in Critically Ill (FS1, FS4, FS7) 8:00-9:30 FS8 Economics of Devices and Support Techniques Sean Bagshaw, MD, MSc, FRCPC Nitin Kohle, MD Antoine Schneider, MD Session 3 of 3 in Economics of Acute Kidney Injury (FS2, FS5, FS8) 8:00-9:30 FS9 Nursing and Pharmacy Research Ian Baldwin, RN, PhD, ACCCN Bruce A. Mueller, PharmD Session 3 of 3 in Research Design and Conduct (FS3, FS6, FS9) 9:30-9:45 Coffee Break SESSION II: CONTROVERSIES IN CRITICAL CARE NEPHROLOGY Plenary 3 MINI-SYMPOSIA Tribal Customs in Critical Care Nephrology: Why We Do What We Do 9:45-12:40 Co-chair: John Prowle, MA MSc MD MRCP FFICM Co-chair: Claudio Ronco, MD Part 1: FLUID Management Strategies for Resuscitation and Hemodynamic Support Recommendations From ADQI 12 9:45-9:55 Assessment of Plasma Volume Bruce A. Molitoris, MD 9:55-10:05 Diagnostics for Vascular Health Can Ince, PhD 10:05-10:15 What Type of Fluid to Give? Patrick T. Murray, MD 10:15-10:25 When and How to Give Fluid Ravindra L. Mehta, MBBS, MD, DM, FACP, 10:25-10:40 Fluid Mobilization Marlies Ostermann, MD Part 2: At Risk for AKI: What Should We Do? 10:40-10:55 ACE/ARB's: Stop or Continue? Chirag Parikh, MD, PhD 10:55-11:10 Focus on Hydration Paul Palevsky, MD 11:10-11:25 Prevention of AKI in Sepsis Michael Joannidis, MD 11:25-11:40 Non-Traumatic Rhabdomyolysis Patrick M. Honoré, MD, PhD 11:40-11:55 Statins for AKI: Friend or Foe? Peter A. McCullough, MD, MPH 11:55-12:15 SPECIAL LECTURE Lessons from Surviving Sepsis Campaign Guidelines Phil Dellinger, MD 12:15-12:30 Panel Discussion 12:30-12:40 Top Abstract Awards 12:40-2:00 Luncheons Hosted by Conference (RSVP Required) Selection made during registration Conference Luncheon ALEXION - Symposium Luncheon Advances in the Diagnosis and Management of Systemic and Progressive TMAs Systemic TMA is a process of widespread thrombi and inflammation in the small blood vessels of vital organs throughout the body. The multiple thrombi and inflammation occurs throughout the body, affecting the brain, kidneys, heart, organs of the gastrointestinal system, and lungs. The clinical presentation of aHUS can have significant clinical overlap (signs and symptoms) with other diseases, some of which are caused by systemic TMA such as TTP and STEC-HUS. Non-CME ASTUTE - Industry Symposium Luncheon New AKI Biomarkers, a Revolution in Risk Assessment Current tools to identify Acute Kidney Injury (AKI) have remained mostly unchanged for decades and have focused primarily on functional renal change. Join this educational symposium to learn about novel AKI biomarkers of early renal stress. Non-CME AGENDA Mink Chawla - Chair and Moderator - 5 mins. Introduction John Kellum - Latest Findings of Cell Cycle Arrest Biomarkers - 25 mins. Andy Shaw - Implications for Management of AKI - 20 mins. Alex Zarbock - Practical Cases - 20 mins. Q&A 10 mins. SPECTRAL DIAGNOSTICS - Focus Group Luncheon Endotoxin Measurements and Treatment for Endotoxemia: Who, How, What and Why Speakers include Dr. Phillip Dellinger, Dr. David Klein and Dr. Gualtiero Guadagni Join us for an update on the EUPHRATES trial. In addition, the discussion will explore the potential role of endotoxin as marker, mediator and potential therapeutic target with PMX in other disease states including trauma, AKI, burns, cardiac surgery and others. Non-CME Thursday Afternoon, March 6 SESSION III: EMERGING CONCEPTS IN AKI AND RRT Plenary 4 MINI SYMPOSIA Targeting Renal Recovery: Report From the Roundtable 2:00-3:30 Co-chair: Dinna Cruz, MD, MPH Co-chair: Li Yang, MD 2:00-2:15 Epidemiology of Renal Recovery: What do We Know? Sean Bagshaw, MD, MSc, FRCPC 2:15-2:30 Biology of Renal Recovery: Molecules, Mechanism and Pathways Mark D. Okusa, MD 2:30-2:45 Enhancing Recovery After AKI: Targets and Interventions Kathleen Liu, MD, PhD, MAS 2:45-3:00 The Economics of Renal Recovery Andrew D. Shaw, MB FRCA FCCM FFICM 3:00-3:15 Management of the AKI Survivor: It Takes a Village Chris McIntyre, MD 3:15-3:30 Long Term Outcomes After Renal Epithelial Cell Cycle Arrest Lakhmir S. Chawla, MD 3:30-3:40 Panel Discussion 3:40-4:00 Coffee Break Plenary 5 MINI SYMPOSIA Challenges and Controversies in Renal Support and CRRT 4:00-6:00 Co-chair: Stuart L. Goldstein, MD Co-chair: Miet Schetz, MD, PhD 4:00-4:15 Circulatory Stress During Dialysis: Contributor to Endotoxemia? Chris McIntyre, MD 4:15-4:30 Can We Use Biomarkers to Refine RRT? Dinna Cruz, MD, MPH 4:30-4:45 Time, Timing and Timeliness: Changing Paradigms for RRT Ravindra L. Mehta, MBBS, MD, DM, FACP, 4:45-5:00 Intradialytic Hypotension: The Holy Grail for RRT Nitin Kohle, MD 5:00-5:15 Peritoneal Dialysis: An Alternate CRRT for AKI? Rajasekara Chakravarthi, MD, DNB (Nephrology) 5:15-5:30 Assessing the Impact of AKI on Convalescent Renal Function at Hospital Discharge John Prowle, MA MSc MD MRCP FFICM 5:30-5:45 Adapting to Adversity: Drug Shortages in CRRT Ashita Tolwani, MD 5:45-6:00 KIDMO - Kidney Interventions During Membrane Oxygenation Geoffrey Fleming, MD 6:00 Adjourn Free Evening Friday Morning, March 7 7:00-1:00 Conference Registration Open 6:30-7:30 Coffee Served SESSION IV: IMPROVING OUTCOMES IN AKI Plenary 6 MINI SYMPOSIA Raising Awareness of AKI 7:30-10:15 Co-chair: Jorge Cerda, MD, FACP, FASN Co-chair: Paul Palevsky, MD 7:30-7:45 Using EMR Data to Identify and Predict AKI Events Scott Sutherland, MD 7:45-8:00 Drug Induced Kidney Injury: Lessons from the O'Brien Center DIRECT Study Linda Awdishu, PharmD, MAS 8:00-8:15 Predicting AKI in the ICU Etienne Macedo, MD, PhD 8:15-8:30 Biomarkers in AKI: Ready for Prime Time? Kianoush Kashani, MD 8:30-8:45 eResearch and Big Data: Why Personalized Medicine is Made For AKI John A. Kellum, MD 8:45-9:00 How do We Improve Global AKI Medical Education Andrew Lewington, MD 9:00-10:15 The Changing Face of AKI: Snapshots from Around the World Emmanuel Burdmann, MD, PhD Zoltan Endre, MD, PhD Vivek Jha, MD Oliver Joannes-Boyau, MD Marlies Ostermann, MD Li Yang, MD Australia - Endre Brazil - Burdmann India - Jha UK - Ostermann Europe - Joannes-Bayou China - Yang Japan - TBN 10:15-10:45 Coffee Break SESSION V: FUTURE TRENDS IN CRRT AND CRITICAL CARE Plenary 7 MINI SYMPOSIA Emerging Strategies in AKI and Extracorporeal Support 10:45-1:00 Co-chair: Vivek Jha, MD Co-chair: Andrew Lewington, MD 10:45-12:30 Update from Ongoing and Late Breaking Trials (approx. 10 minutes each) Sean Bagshaw, MD, MSc, FRCPC Robert Brenner, MD Phil Dellinger, MD John A. Kellum, MD Samina Khan, MD Bhupinder Singh, Dr. James A. Tumlin, MD 1. Polymixin Binding Filter for Sepsis: EUPHRATES Trial - Dellinger 2. ZS-9 Trial - Singh 3. Stem Cells for AKI: Allocure Trial - Brenner 4. STARRT Trial Timing of Dialysis - Bagshaw 5. Abbvie Trial for Post Op AKI - Khan 6. Thrasos Trial for Post Cardiac Surgery AKI - Tumlin 7. Topaz Trial - Kellum 12:30-12:55 Critical Care Nephrology: Literature Review Noel Gibney, MB FRCP(C) 12:55-1:00 Closing Remarks Ravindra L. Mehta, MBBS, MD, DM, FACP, 1:00 Conference Adjourns