Search © 2013 CRRT Inc. CRRT 2013 Conference - Program and Workshops Complete CRRT Brochure PDF (988K) Monday, February 11 5:00-8:00pm Conference Registration Open Pre-Conference AKI Symposium Tuesday, February 12 7:00am Conference and Workshop Registration Open 8:00-5:30 PW1 Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management sponsored by: The UAB-UCSD O'Brien Core Center for Kidney Injury Research Acute Kidney Injury is a rapidly evolving area where several advances have been made in understanding the mechanisms and pathways of AKI and its effects on other organs. Recent identification of biomarkers has provided new tools and techniques to characterize this disorder. This pre-course workshop will provide a comprehensive review of the most recent developments in the field and describe emerging knowledge from basic and translational research. Results from clinical trials will be discussed to define the best strategies for effective management of patients and define the criteria for future studies. CRRT Conference registration is not required to attend this symposium, separate registration is available. 7:55-8:00 Opening Remarks Ravindra L. Mehta, MBBS, MD, DM, FACP, AKI Symposium - Plenary 1 Molecules, Mechanisms and Targets 8:00-10:00 Co-chair: Anupam Agarwal, MD Co-chair: Roland C. Blantz, MD 8:00-8:20 PW1 Ischemic Preconditioning and the Cytoresistant State Richard Zager, MD 8:20-8:40 Mitochondrial Dysfunction in AKI Samir Parikh, MD 8:40-9:00 Glomerular Participation in Ischemic and Septic AKI Bruce A. Molitoris, MD 9:00-9:20 Vasopressin Analogues in Septic Shock: Implications for the Kidney Martin Westphal, MD 9:20-9:40 Novel Mechanisms of Progression of AKI to CKD Joseph V. Bonventre, MD, PhD 9:40-10:00 Regulatory T Cells: Quelling the Storm Mark D. Okusa, MD 10:00-10:15 Coffee Break AKI Symposium - Plenary 2 Translational Research: Bedside to Bench and Back 10:15-12:15 Co-chair: John A. Kellum, MD Co-chair: Bruce A. Molitoris, MD 10:15-10:35 MRI Imaging: Real time Assessment of Renal Physiology Dileep N. Lobo, MD 10:35-10:55 Alkaline Phosphatase for Kidney Injury in Sepsis John Louis Vincent, MD PhD 10:55-11:15 Is Choride a Problem? Rinaldo Bellomo, MD 11:15-11:35 Is AKI Pro-inflammatory or Anti-inflammatory? Sarah Faubel, MD 11:35-11:55 Complement Mediated Renal Injury Joshua Thurman, MD 11:55-12:15 Emerging Strategies for Management of AKI in Cirrhosis: Targeting the Gut-Liver-Kidney Rajiv Jalan, MD, PhD 12:15-1:15 Lunch Hosted by Conference for Workshop Participants AKI Symposium - Plenary 3 Of Mice and Men: Developing Relevant Models for Translational Research 1:15-3:15 Co-chair: Rinaldo Bellomo, MD Co-chair: Paul Sanders, MD 1:15-1:35 Pre-Clinical Models for Translational Research in AKI Volker Vallon, MD 1:35-1:55 Studying Renal Physiology In-vivo Can Ince, PhD 1:55-2:15 Acute Renal Failure Around the World: Lessons from the ICON Study John Louis Vincent, MD PhD 2:15-2:35 Cell-cycle Arrest Biomarkers of AKI John A. Kellum, MD 2:35-2:55 Efficient Trial Designs for Novel Drug and Biologics in AKI William L. Macias, MD, PhD 2:55-3:15 Prevention Trials in AKI: Lessons from PRESERVE Paul Palevsky, MD 3:15-3:30 Coffee Break AKI Symposium - Plenary 4 Tools to Characterize Human AKI 3:30-5:30 Co-chair: Mark D. Okusa, MD Co-chair: Paul Palevsky, MD 3:30-3:50 Novel Compounds for the Treatment of Acute Kidney Injury Mitchell H. Rosner, MD 3:50-4:10 Disentanglement of the AKI Syndrome Lakhmir S. Chawla, MD 4:10-4:30 How Should We Use Biomarkers in AKI: An Update from the ADQI Conference Patrick T. Murray, MD 3:30-3:50 AKI Biomarkers: Does Their Performance in Different Population Lend Insight Into Mechanisms? David Askenazi, MD 4:50-5:10 Determining Long Term Outcomes From AKI: The ARID Study Chris McIntyre, MD 5:10-5:30 Innovations in Extracorporeal Support: What?s Emerging? Claudio Ronco, MD 5:30pm AKI Workshop Adjourns Fundamentals of CRRT Tuesday, February 12 HW1 Fundamentals of CRRT This workshop offers an introduction to CRRT techniques and is developed to provide a core set of information on the principles and practice of CRRT. This workshop will cover the components and basic principles of continuous renal replacement therapy. The operating characteristics of CRRT techniques for solute and fluid management, drug management will be discussed along with the potential applications of these techniques. Requirements for developing a successful CRRT program and selecting machines will also be described. Full Day Concurrent Workshop - HW1 8:00-5:30 7:55-8:00 HW1 Opening Remarks Jorge Cerda, MD, FACP, FASN Ashita Tolwani, MD 8:00-8:30 HW1 Operating Principles of CRRT William R. Clark, MD 8:30-9:00 Access/Membrane and Circuit Luis Juncos, MD 9:00-9:30 Anticoagulation Ashita Tolwani, MD 9:30-10:00 Solute Control and Dose Rolando Claure, MD 10:00-10:15 Discussion 10:15-10:30 Coffee Break 10:30-11:00 Solutions Ashita Tolwani, MD 11:00-11:30 Fluid Management Ravindra L. Mehta, MBBS, MD, DM, FACP, 11:30-12:00 Drug Management Patrick M. Honoré, MD 12:00-12:30 Patient Selections and Outcomes Jorge Cerda, MD, FACP, FASN 12:30-1:15 Lunch Hosted by Conference for Workshop Participants 1:15-1:45 Organizational and Financial Aspects Jorge Cerda, MD, FACP, FASN 1:45-2:15 Pharmacy Support Linda Awdishu, PharmD, MAS 2:15-2:45 Nursing Issues Eileen Lischer, MA, BSN, RN, CNN 2:45-3:15 Nutritional Support Michael Connor, MD 3:15-3:30 Coffee Break 3:30-4:00 Monitoring and Preventing Complications Marlies Ostermann, MD 4:00-4:30 CRRT Outcome Studies Sean Bagshaw, MD, MSc, FRCPC 4:30-5:00 Available Technology Noel Gibney, MB FRCP(C) 5:00-5:30 Questions and Discussion Jorge Cerda, MD, FACP, FASN Ashita Tolwani, MD 5:30pm Adjourn HW2, HW3, IND1 Half Day Workshops Tuesday, February 12 Half Day Concurrent Workshops - HW2, HW3, IND1 10:30-3:30 10:30-3:30 HW2 Pediatric Hands-On Workshop Steven R. Alexander, MD Amelia Allsteadt, BSN,RN,CNN Helen Currier, BSN, RN, CNN, CENP Jolyn Morgan, RN, CDN Theresa Mottes, RN Alisa Palazzolo, BSN, RN II This workshop will focus upon the practical aspects of care including clinical program development, discussion of various models of ICU and Nephrology medical nursing care and hands on machine setup and operation. 10:30-3:30 HW3 Hemodynamic Monitoring and Use of Drugs Can Ince, PhD Kianoush Kashani, MD Andrew D. Shaw, MB FRCA Critically ill Patients require frequent assessments and monitoring of hemodynamic and respiratory parameters to optimize stability and guide ventilator support. Several techniques are now available and utilized to manage patients including devices to assess the microcirculation, volume responsiveness and cardiac performance. This workshop will cover the principles and strategies for hemodynamic and microcirculatory monitoring in critically ill patients. 10:30-3:30 IND1 Gambro Physician's Hand-On Workshop Practical CRRT - The Nuts and Bolts Through case studies, lecture and Prismaflex System hands-on practice, this workshop will provide practical approaches to prescribing and delivering CRRT with Gambro's leading CRRT system. CME Credits Do Not Apply Presented by: Luis Alvarez, MD PhD, Stanford University Medical Center 12:15-1:15 Lunch Hosted by Conference for Workshop Participants 1:15-3:30 Half Day Workshops Continue Tuesday, February 12 Standard Workshops Open to all participants and applicable to physicians, nurses and allied personnel. (Codes: C= Core workshop, I = Intermediate, A = Advanced, N= Nurses, AP = of interest to nurses and allied personnel) Workshops presented in a series are marked with a 1 for a primary workshop discussion in this area and 2 for a more complex or advanced discussion in this area. Please note that the series workshops 1 and 2 can be either taken subsequently (following each other) or they can each be taken independently (e.g. workshop 1 can be taken without taking workshop 2 and vice versa). Workshop Group 1 4:00-5:30 4:00-5:30 A01 Physiologic Biomarkers of Renal Function (C, N, AP) Can Ince, PhD Etienne Macedo, MD, PhD Renal functional biomarkers including urine electrolytes , GFR and RBF measurements contrast and Doppler ultrasound, MRI imaging. Assessment of the microcirculation to assess tissue perfusion will be shown. 4:00-5:30 B02 Strategies for Optimizing the CRRT Circuit (I, N, AP) Ian Baldwin, RN, PhD, ACCCN Stuart L. Goldstein, MD Luis Juncos, MD Case based discussions on best practices to maintain circuits for CRRT focusing on the Access, Anticoagulation and Monitoring 4:00-5:30 C03 Critical Care Pharmacology: Vasopressors, and Inotropes (A, N, AP) John Louis Vincent, MD PhD Martin Westphal, MD Pathophysiology of shock and the principles and practical use of vasopressors, ionotropes, vasodilators in critically ill patients. 4:00-5:30 D04 Vexing Problems in ICU Patients 1: Acid Base and Electrolyte Problems (C, N, AP) Sarah Faubel, MD Marlies Ostermann, MD Mitchell H. Rosner, MD Test and update your knowledge with these interactive case studies focused on recognizing and managing acid base and electrolyte problems in critically ill patients. 4:00-5:30 E05 Managing Patients with AKI and Liver Failure 1: Pathophysiology, Differential Diagnosis, Therapy, Monitoring (C, N, AP) Robert Gish, MD Rajiv Jalan, MD, PhD Pathophysiology of AKI in setting of acute and chronic hepatic failure and management strategies for differential diagnosis and therapy 4:00-5:30 F06 Competency Assessment in Renal Support Techniques in the ICU (C, N) Helen Currier, BSN, RN, CNN, CENP Patty Graham, RN, MS, CCRN, CS Eileen Lischer, MA, BSN, RN, CNN Description on training requirements, core curriculum and skills assessment for CRRT care delivery. 4:00-5:30 G07 Renal Support in the ICU with IHD, PIRRT, PD, Hybrid Devices (A) Richard Amerling, MD Thomas A. Golper, MD Balazs Szamosfalvi, MD Comparisons of operational characteristics including anticoagulation, membranes, solutions and flows and approaches for ongoing and future research. 4:00-5:30 H08 Preventing and Managing Complications of Dialysis 1: Intradialytic Hypotension (C, N) Amelia Allsteadt, BSN,RN,CNN Andrew Davenport, MD, FRCP Chris McIntyre, MD 4:00-5:30 ME1 Meet the EXPERT 1: How Do I Assess Risk for AKI and Manage High Risk Surgical and ICU Patients Kathleen Liu, MD, PhD, MAS Andrew D. Shaw, MB FRCA Device demonstrations of features, setup, operation, monitoring and discontinuation 6:00-7:30pm Reception and Poster Review Special Oral Abstract Presentation Sessions 6:15-7:30 Moderators: A. Mark Okusa, MD & Dinna Cruz, MD B. Miet Schetz, MD & Richard Amerling, MD C. Josee Bouchard, MD & Kazo Kaizu, MD Wednesday Morning, February 13 7:00-4:30pm Conference Registration Open Workshop Group 2 8:30-10:00 8:30-10:00 A09 Using Kidney Biomarkers for AKI 1: Risk Assessment, Diagnosis and Staging (C, N, AP) Joseph V. Bonventre, MD, PhD Josée Bouchard, MD Patrick T. Murray, MD Practical issues for use of kidney biomarkers for assessing risk and for early recognition and interventions in AKI. 8:30-10:00 B10 CRRT for the Experienced User 1 (I, N, AP) William R. Clark, MD Rolando Claure, MD Claudio Ronco, MD Interactive case based discussions on dose adjustments, monitoring for adequacy, modality selection and transitions in CRRT. 8:30-10:00 C11 Critical Care Management: Nutrition Assessment and Delivery (I, N, AP) Michael Connor, MD Dileep N. Lobo, MD Pathophysiology of malnutrition in critically ill patients. Principles of nutritional assessment and support and adjustments for RRT. 8:30-10:00 D12 Vexing Problems in ICU Patients on RRT 2: Drug Management for Problematic Infections, Sedation, Organ Support (I, N, AP) Saima Aslam, MD Patrick M. Honoré, MD Miet Schetz, MD, PhD Case based discussions for adjustments in drug dosing, renal support and monitoring of complex ICU patients with comorbidities and drug resistant infections. 8:30-10:00 E13 Managing Patients with AKI and Liver Failure 2: Use of RRT, Liver Support, Strategies for Bridge to Transplant (A, N) Andrew Davenport, MD, FRCP Nigel Fealy, RN, MN, ACCCN Heather Patton, MD Interactive case studies describing the rationale for use of different extracorporeal support techniques (Cell based systems, MARS, CRRT) for hepatic support as a bridge to transplant or functional recovery. 8:30-10:00 F14 Patient Centered Care in the ICU: The Team Approach (C, N, AP) Steven R. Alexander, MD Ian Baldwin, RN, PhD, ACCCN Patty Graham, RN, MS, CCRN, CS Taking good care of patients requires communication and understanding of patient and loved ones' needs. This workshop will discuss the principles and practice of patient centered care utilizing case studies. 8:30-10:00 G15 Plasma Exchange Therapy and Hybrid Techniques (C, N, AP) Hiroyuki Hirasawa, MD David M. Ward, MD, FRCP Principles of plasma exchange, sorbent based and hybrid therapies for extracorporeal support and case based discussion of practical application. 8:30-10:00 H16 Preventing and Managing Complications of Dialysis 2: Operation, Fluids, Electrolytes and Acid Base (C, N) Sean Bagshaw, MD, MSc, FRCPC Emmanuel Burdmann, MD, PhD Chris McIntyre, MD Case based discussions of related complications in ICU patients. 8:30-10:00 ME2 Meet the Expert 2: How I Assess Patients in the ICU and My Approach to Oliguria Rajiv Jalan, MD, PhD John Louis Vincent, MD PhD 10:00-10:15 Coffee Break Workshop Group 3 10:15-11:45 10:15-11:45 A17 Using Kidney Biomarkers for AKI 2: Differential Diagnosis, Interventions and Prognosis (C, N, AP) Rajit Basu, MD Lakhmir S. Chawla, MD Strategies for the effective use of kidney biomarkers for managing patients with AKI to guide interventions and predict outcomes. 10:15-11:45 B18 CRRT for the Experienced User 2: Solutions, Fluid Removal Fluid Balance, Monitoring (C, N, AP) Ian Baldwin, RN, PhD, ACCCN Ravindra L. Mehta, MBBS, MD, DM, FACP, Interactive case based discussion on strategies for fluid management in CRRT to achieve patient driven outcomes for fluid, electrolyte and acid base balance. 10:15-11:45 C19 Fluids and Solutions in the Critically Ill 1 (I) Marlies Ostermann, MD Andrew D. Shaw, MB FRCA Martin Westphal, MD How to select and use colloids, crystalloids and blood products. 10:15-11:45 D20 Managing Patients with Sepsis 1 : Pathophysiology, Diagnosis, Assessment, Resuscitation and Drug Management (A) Rinaldo Bellomo, MD Geoffrey Fleming, MD Samir Parikh, MD Case based discussions on pathophysiology of sepsis, rationale and strategies for fluid and vasopressor use for resuscitation and supportive therapy with the sepsis bundle. 10:15-11:45 E21 Managing Heart Failure and Cardiorenal Syndrome 1: Pathophysiology, Diagnosis, Drug Management (I) Dinna Cruz, MD, MPH Patrick T. Murray, MD Pathophysiology, recognition and management strategies for cardiac and renal failure in the critically ill patient. 10:15-11:45 F22 Ensuring Patient Safety and Quality Measures for RRT in AKI 1: Water Standards, Infection Control (C, N, AP) Richard Amerling, MD Saima Aslam, MD Thomas A. Golper, MD Discussion of the recent developments in ensuring quality and patient safety for acute dialysis delivery. 10:15-11:45 G23 Pediatric CRRT: The Basics (I, N, AP) Theresa Mottes, RN Scott Sutherland, MD Jordan M. Symons, MD Technique requirement and application for use in children excluding neonates. Covering epidemiology of pediatric acute kidney injury, and a focus on the pediatric CRRT prescription (anticoagulation, fluid composition, modality, and nutrition provision), as well as outcome in pediatric CRRT. 10:15-11:45 H24 Withdrawing & Withholding Support for AKI: Ethical Issues in the ICU (I, N, AP) Steven R. Alexander, MD Rolando Claure, MD Noel Gibney, MB FRCP(C) Charuhas Thakar, MD Factors influencing decisions for withholding and withdrawing dialysis in the management of critically ill patients. General principles for ethical decisions and how an approach can be developed to manage patients requiring dialysis. 10:15-11:45 ME3 Meet the Expert 3: How I Use the KDIGO AKI Guidelines to Manage Patients John A. Kellum, MD Claudio Ronco, MD 11:45-1:00 Luncheons Hosted by Conference (RSVP Required) Selection made during registration Conference Luncheon GAMBRO - Symposium Luncheon Rinaldo Bellomo, MD Does CRRT Improve Renal Recovery? Dr. Rinaldo Bellomo, Principal Investigator for the RENAL Study, will present findings on the impact of renal replacement therapy modality on renal recovery in survivor’s of severe acute kidney injury. Non-CME ALEXION - Symposium Luncheon Advances in the Diagnosis and Management of Systemic and Progressive Thrombotic Microangiopathies (TMA's) Systemic TMA is a process of widespread thrombi and inflammation in the small blood vessels of vital organs throughout the body. The multiple thrombi and inflammation occurs throughout the body, affecting the brain, kidneys, heart, organs of the gastrointestinal system, and lungs. The clinical presentation of aHUS can have significant clinical overlap (signs and symptoms) with other diseases, some of which are caused by systemic TMA such as TTP and STEC-HUS. Non-CME ALERE Focus Group Luncheon Rethinking AKI: The Importance of Subclinical Injury The concept of subclinical acute kidney injury suggests the need to revisit consensus criteria for AKI. Changes in novel biomarkers, such as NGAL, may have clinical relevance even in the absence of traditional parameters used to diagnosis AKI. A faculty of experts will discuss the value in identifying subclinical injury, related patient impact and potential role for NGAL. Non-CME Fresenius Kabi Focus Group Luncheon Volume Therapy in Critically Ill Patients: Misconceptions versus Facts This interactive session includes two lectures on volume therapy and the importance of fluid balance of critically ill patients. Misconceptions versus available evidence will be critically discussed to enable a safe and efficient volume therapy in the intensive care unit. Non-CME Fiction and Facts of Volume Therapy in the Intensive Care Unit Presented by: Hrishikesh Kulkarni, MD Effects of Fluid Composition and Volume on the Vulnerable Kidney Presented by: Can Ince, PhD SESSION I: PATIENT CHARACTERISTICS Plenary 1 MINI-SYMPOSIA Organ Dysfunction in the Critically Ill Patient: Emerging Concepts 1:10-3:45 Co-chair: William L. Macias, MD, PhD Co-chair: Mark D. Okusa, MD 1:10-1:15 Opening Remarks Ravindra L. Mehta, MBBS, MD, DM, FACP, 1:15-1:30 ICU Nephrology: The Implications of Cardiovascular Alterations in the Acutely Ill John Louis Vincent, MD PhD 1:30-1:45 Pathophysiology and Management of Post-cardiac Arrest Syndrome Hiroyuki Hirasawa, MD 1:45-2:00 Acute Kidney Injury and Sepsis: A Toll Like Receptor (TLR) Hyper-Responsive State Richard Zager, MD 2:00-2:15 The Angiopoietins in Sepsis: Markers and Potential Mediators of Vascular Leak and Injury Samir Parikh, MD 2:15-2:30 Metabolic conditioning and Nutritional Modulation for Improving Perioperative Outcomes Dileep N. Lobo, MD 2:30-2:45 Acute Lung injury and ARDS: What?s New? Kathleen Liu, MD, PhD, MAS 2:45-3:15 SPECIAL LECTURE The Global Renal Circulation in Sepsis Rinaldo Bellomo, MD 3:15-3:45 Panel Discussion John A. Kellum, MD 3:45-4:15 Coffee Break Plenary 2 MINI-SYMPOSIA Acute Kidney Injury (AKI): Pathophysiology 4:15-6:30 Co-chair: Li Yang, MD Co-chair: Richard Zager, MD 4:15-4:30 Is Restoration of a Near Normal Milieu Advantageous in AKI? Bruce A. Molitoris, MD 4:30-4:45 Normal and Maladaptive Repair After Injury Joseph V. Bonventre, MD, PhD 4:45-5:00 Pathophysiology of Plasma Cell Dyscrasias: A Model for Targeted Intervention Paul Sanders, MD 5:00-5:15 Systemic Effects of AKI Sarah Faubel, MD 5:15-5:30 Differential Diagnosis and Therapeutic Strategies of Thrombotic Micro Angiopathies (TMA) Joshua Thurman, MD 5:30-5:45 Cardio-Renal Interactions in Heart Failure: An update from the ADQI 11 Conference Claudio Ronco, MD 5:45-6:00 Panel Discussion Anupam Agarwal, MD 6:00-6:30 SPECIAL SESSION Critical Care Nephrology Jeopardy Nephrologists vs Intensivists Noel Gibney, MB FRCP(C) 6:30 Adjourn 6:30-8:00 Exhibit Reception and Poster Session Thursday Morning, February 14 7:00am-4:30pm Registration Open 7:00-8:00 Continental Breakfast Workshop Group 4 8:00-9:30 8:00-9:30 A25 Raising Awareness of AKI: Risk, Recognition, and Response (C, N, AP) Jorge Cerda, MD, FACP, FASN Stuart L. Goldstein, MD Andrew Lewington, MD This workshop will describe the urgent need for educating care givers, patients and the lay public on the devastating effects of AKI. Strategies and tools for risk assessment, recognition and early response for AKI will be discussed. 8:00-9:30 B26 CRRT for the Experienced User 3: Technique Adjustments Case Studies (A) Ian Baldwin, RN, PhD, ACCCN Michael Connor, MD Ashita Tolwani, MD Interactive cases demonstrating the flexibility and adaptiveness of CRRT techniques for dynamic comprehensive renal support. 8:00-9:30 C27 Drug Induced Kidney Injury in the ICU: Mechanisms, Susceptibility, Diagnosis, Management Strategies (A, N) Kathleen Liu, MD, PhD, MAS Bruce A. Mueller, PharmD, FCCP, FASN Mitchell H. Rosner, MD Causes and consequences of drug induced nephrotoxicity, factors contributing to toxicity, strategies for preventing and managing toxicity. Utilization of dialysis techniques for drug removal. 8:00-9:30 D28 Managing Patients With Sepsis 2: Techniques for Disease Modification, Organ Support and Renal Protection (A) Hiroyuki Hirasawa, MD Patrick M. Honoré, MD Technical considerations and practical application of extracorporeal support techniques for sepsis. Results of human studies for use of high permeability membranes, HVHF, VHVHF and hybrid techniques for sepsis. 8:00-9:30 E29 Managing Heart Failure and Cardio-Renal Syndrome 2: Ultrafiltration, Renal Support and RRT for Patients with Ventricular Assist Devices and Artificial Hearts (A, N)) Dinna Cruz, MD, MPH Luis Juncos, MD Emil P. Paganini, MD, FACP, FRCP Technical considerations, practical application and results of different methods to treat heart failure and cardio-renal syndrome including ultrafiltration techniques. 8:00-9:30 F30 Ensuring Patient Safety and Quality Measures for RRT in AKI 2: Dialysis Adequacy, Monitoring, Nursing Issues (C, N, AP) Linda Awdishu, PharmD, MAS Eileen Lischer, MA, BSN, RN, CNN Ashita Tolwani, MD Discussion of the principles of a systems based approach to implementing and monitoring quality to reduce errors in therapy prescription and delivery. 8:00-9:30 G31 CRRT in the Newborn: Principles and Practical Issues (C, N, AP) David Askenazi, MD Scott Sutherland, MD Pathophysiology and management of metabolic disorders, neonatal AKI and intoxications with CRRT. 8:00-9:30 H32 Starting and Stopping RRT for AKI: Principles and Practice (I, N, AP) Etienne Macedo, MD, PhD Ravindra L. Mehta, MBBS, MD, DM, FACP, Principles of determining when to start and stop RRT. Case based discussion of various approaches. 8:00-9:30 ME4 Meet the Expert 4: How I Design and Conduct Clinical Trials in AKI Rinaldo Bellomo, MD William L. Macias, MD, PhD Paul Palevsky, MD 9:30-9:45 Coffee Break SESSION II: EMERGING CONCEPTS IN AKI AND CRITICAL CARE Plenary 3 MINI-SYMPOSIA Controversies in Management of the Critically Ill Patient: Fluid Management and Renal Protection 9:45-12:40 Co-chair: Sarah Faubel, MD Co-chair: Claudio Ronco, MD 9:45-10:00 Does Sedation Affect Kidney Function? Andrew D. Shaw, MB FRCA 10:00-10:15 How Much fluid is Enough for AKI? Kathleen Liu, MD, PhD, MAS 10:15-10:30 Does Fluid Composition Influence Renal Function? Dileep N. Lobo, MD 10:30-10:45 Achieving Fluid balance and Preserving Kidney Function: The Role of CRRT! Ravindra L. Mehta, MBBS, MD, DM, FACP, 10:45-11:00 Heart Failure Management: Implications for the Kidney Patrick T. Murray, MD 11:00-11:15 How Should You Manage Oliguria Sean Bagshaw, MD, MSc, FRCPC 11:15-11:30 Fluid Resuscitation Strategies Lessons from the 6S and CHEST Trials Rinaldo Bellomo, MD 11:30-12:15 Controversies: What Fluids Should be Used for Resuscitation to Protect the Kidney? Bicarbonate - P. Palevsky Colloids - D. Lobo Blood - C. Ince Anything but Saline - J. Kellum They Are All OK if Used Cautiously - M. Westphal Can Ince, PhD John A. Kellum, MD Dileep N. Lobo, MD Paul Palevsky, MD Martin Westphal, MD 12:15-12:30 Panel Discussion Noel Gibney, MB FRCP(C) 12:30-12:40 Top Abstract Awards 12:40-2:00 Luncheons Hosted by Conference (RSVP Required) Selection made during registration Conference Luncheon Nursing Forum Luncheon Kevin Patrick, MD, MS Mapping the Exposome: How Wireless Technology and Social Media are Changing Our Perceptions of Medical Care The rapid explosion of wireless technology and social media applications is leading to the development of sensor based technologies that will revolutionize our approach to research and medicine. This special lecture will describe some of the innovations that are being deployed and what they will mean for care delivery in the near future. CME Available Astute - Industry Symposium Luncheon New AKI Biomarkers, a Revolution in Risk Assessment Current tools to identify Acute Kidney Injury (AKI) have remained mostly unchanged for decades and have focused primarily on functional renal change. Join this educational symposium to learn about novel AKI biomarkers. Non-CME Spectral Diagnostics Inc. Focus Group Luncheon Endotoxemia is Related to Sepsis, Sepsis is Related to AKI, ergo...Endotoxemia is Related to AKI? Using the Endotoxin Activity Assay, there is renewed evidence that endotoxemia is a major mediator of sepsis (1). Likewise, septic AKI has been shown to impart a significantly higher mortality risk than non-septic AKI (2). The EUPHAS trial provided evidence that removal of endotoxin results in improved kidney function(3) and the proposed mechanisms of injury have been described by Ranieri et al (4). Can it be deduced that endotoxemia is related to AKI and that its removal and subsequent renal function improvements are related to improved mortality? Stay tuned, the EUPHRATES trial intends to provide the answer. (1)Romaschin, Klein, & Marshall, CCM 2012, 16:248.(2)Honore, et al. Annals of Intensive Care 2011, 1:32.(3)Cruz et al, JAMA 2010.(4)Ranieri et al,ICM, 2009. Non-CME SESSION II: EMERGING CONCEPTS IN AKI AND CRITICAL CARE Plenary 4 MINI SYMPOSIA Drug Induced Kidney Injury: From Mechanisms to Management 2:00-3:30 Co-chair: Josée Bouchard, MD Co-chair: Patrick T. Murray, MD 2:00-2:15 Mechanisms of Drug Nephrotoxicity Bruce A. Mueller, PharmD, FCCP, FASN 2:15-2:30 Genetic Determinants of Drug Induced Kidney Injury Linda Awdishu, PharmD, MAS 2:30-2:45 Nephrotoxic Medication Associated AKI in Children: The Epidemic Exists Stuart L. Goldstein, MD 2:45-3:00 Drug Dosing During Extracorporeal Support: Can We Protect the Kidney? Miet Schetz, MD, PhD 3:00-3:15 Renal Toxicity of Recreational Drugs Richard F Clark, MD 3:15-3:30 EXTRIP: What and Who is it? Kathleen Liu, MD, PhD, MAS 3:30-4:00 Coffee Break Plenary 5 MINI SYMPOSIA Challenges and Controversies in Renal Support and CRRT 4:00-6:00 Co-chair: Emmanuel Burdmann, MD, PhD Co-chair: Andrew Davenport, MD, FRCP 4:00-4:15 Circulatory Stress During Dialysis: Contributor to Endotoxemia? Chris McIntyre, MD 4:15-4:30 Permissive Hypofiltration Lakhmir S. Chawla, MD 4:30-4:45 Automated Citrate Anticoagulation for Dialysis Balazs Szamosfalvi, MD 4:45-5:00 RRT for the Morbidly Obese Patient: Challenges and Solutions Charuhas Thakar, MD 5:00-5:15 Prolonged Intermittent Dialysis: Experience with Different Modalities Etienne Macedo, MD, PhD 5:15-5:30 Extracorporeal Support for the Patient with an Artificial Heart and Heart Assist Devices Luis Juncos, MD 5:30-5:45 Preventing and Managing Catheter Based Infections Saima Aslam, MD 5:45-6:00 Treatment of Refractory Ascites: Taps, TIPSS and Now Pumps Rajiv Jalan, MD, PhD 6:00 Adjourn Free Evening Friday Morning, February 15 7:00-1:00 Conference Registration Open 6:30-7:30 Continental Breakfast SESSION III: TECHNIQUE CHARACTERISTICS Plenary 6 MINI SYMPOSIA Raising Awareness of AKI 7:30-10:00 Co-chair: Steven R. Alexander, MD Co-chair: Mitchell H. Rosner, MD 7:30-7:45 Raising Awareness: What Are the Issues? Jorge Cerda, MD, FACP, FASN 7:45-8:00 Lessons from the O'Brien Center International AKI Registry Josée Bouchard, MD 8:00-8:15 Kidney Attack in the ICU: The Epidemic is Here John A. Kellum, MD 8:15-8:30 Derivation, Validation and Application of the Renal Angina Index in Critical Illness Rajit Basu, MD 8:30-8:45 Surveillance with an EMR: Does it Make a Difference? Kianoush Kashani, MD 8:45-9:00 Improving Outcomes from AKI: Lessons from the UK Andrew Lewington, MD 9:00-10:15 The Changing Face of AKI: Snapshots from Around the World Brazil, Japan, China, UK, Canada, Australia, USA, Europe Rinaldo Bellomo, MD Emmanuel Burdmann, MD, PhD Andrew Davenport, MD, FRCP Kent Doi, MD Amit Garg, MD Stuart L. Goldstein, MD Patrick M. Honoré, MD Ashita Tolwani, MD Li Yang, MD 10:15-10:45 Coffee Break SESSION IV: FUTURE TRENDS IN CRRT AND CRITICAL CARE Plenary 7 MINI SYMPOSIA Emerging Strategies in AKI and Extracorporeal Support 10:45-1:00 Co-chair: Thomas A. Golper, MD Co-chair: Etienne Macedo, MD, PhD 10:45-12:30 Update from Ongoing and Recent Trials (12 minutes each) 1. Ultrafiltration for Heart Failure: CARESS Trial - E. Paganini 2. Curcurumin for AKI - A.Garg 3. SCD Immunomodulation for AKI - J. Tumlin 4. Polymixin Binding Filter for Sepsis: EUPHRATES Trial - S. Bagshaw 5. Cytokine-Adsorbing Hemofilter CHDF for Sepsis - H. Hirasawa 6. Pre-mixed Citrate Solutions for CRRT - P. Honore 7. Prospective Observational Trial of Post-CABG AKI Using Defined Entry Criteria: Prelude to Thrasos BMP7 Trial - J. Tumlin Sean Bagshaw, MD, MSc, FRCPC Amit Garg, MD Hiroyuki Hirasawa, MD Patrick M. Honoré, MD Emil P. Paganini, MD, FACP, FRCP James A. Tumlin, MD 12:30-12:55 Critical Care Nephrology: Literature Review Noel Gibney, MB FRCP(C) 12:55-1:00 Closing Remarks Ravindra L. Mehta, MBBS, MD, DM, FACP, 1:00 Conference Adjourns