SUNDAY, March 2, 2025

12:30pm-5:00pm Conference Registration Open for Pre-conference Electives Participants Only – Regatta Foyer
• CRRT Workshop
• NEXUS Pediatric Workshop
• POCUS Workshop
• AKI Symposium

PRE-CONFERENCE ELECTIVE CRRT WORKSHOP – DAY 1 (CME Available for a fee)

Practice Based Learning in CRRT: The Science and the Art

1:30pm – 6:00pm

This workshop is designed to provide participants with the knowledge and understanding for the effective utilization of CRRT to manage critically ill patients. Session 1 on Sunday focuses on the fundamentals of CRRT including the components, operational characteristics and characteristics, solute and fluid management and monitoring. Session 2 on Monday will utilize case-based discussions and interactive sessions to illustrate the underlying concepts for application of CRRT in different situations. Delegates will participate in group exercises to apply their learning for the management of complex cases. At the end of this workshop participants will have an improved understanding of how to utilize CRRT for optimizing renal support. A quiz will be administered pre-and post- course for assessment.

Learning Objectives:
• Describe the underlying concepts and review the process of decision making for prescribing and delivering CRRT
• Learn machine set-up for different modalities, alarm conditions, troubleshooting, monitoring and charting
• Utilize the tools provided to manage complex cases

Co-Chairs: Ashita Tolwani, MD and Jorge Cerda, MD

Sunday AFTERNOON – SESSION 1 (Day 1)

1:30-6:00pm CRRT PRINCIPLES
1:30-1:45pm Opening Remarks – Ashita Tolwani, Jorge Cerda
1:45-2:00 Introduction to CRRT Master Class – Ashita Tolwani
2:00-2:30 Patient Selection, Modality, and Dose – Jorge Cerda
2:30-3:15 The ABC of the CRRT Prescription – Ashita Tolwani
3:15-3:45 Access, Membrane, Circuit – Manish Kaushik
3:45-4:15 Solutions and Fluid Balance – Javier Neyra

4:15-4:30 Coffee Break

4:30-4:50 Drug Dosing and Adjustments – Linda Awdishu
4:50-5:10 Nutritional Support During CRRT – Michael Connor
5:10-6:00 Dysnatremias and Acid Base Disorders – Lenar Yessayan

6:00 pm Adjourn (resume Monday morning)

PRE-CONFERENCE ELECTIVE NEXUS PEDIATRIC WORKSHOP – HALF DAY (Non-CME)

NEXUS

Click Here to view the workshop flyer (pdf)
1:00pm – 6:15pm

Progress to improve care for children with critical care nephrology related illnesses continues.To continue a movement towards collaborative innovation, education, and study, the NEXUS is a symposium to focus the global approach to care for critically ill neonates and children. NEXUS is a joint session betweenall pediatric critical care nephrology care providers, industry partners, and thought leaders in the spaces of diagnostics, therapeutics, advocacy, and education.

AGENDA
1:00-1:15 Welcome to the NEXUS
1:15-2:15 Pediatric Collaboratives – Around the Horn
2:15-3:15 Refreshment & Networking Session #1 – “What are the questions we aren’t asking?”
3:15-4:15 The Next Big Ideas (x3) – Jr. Faculty Led Sessions
4:15-5:15 The Industrial Pediatric Revolution: The Newest Paths in the Road
5:15-6:15 Refreshment & Interactive Session #2 – “Going Faster”
6:15-6:30 Sharing of Ideas / Concluding Statements
6:15-7:15 Adjourn/Break
7:15-10:00 Dinner

FACULTY
David Askenazi, Rajit K. Basu, Stuart Goldstein, Theresa Mottes, Dana Fuhrman and Timothy Bunchman

Monday Morning, March 3, 2025

7:00am-12pm Conference Registration Open for Pre-conference Electives Participants Only – Coronado Foyer
• CRRT Workshop (Day 2)
• AKI Symposium
• POCUS Workshop

3:30pm-7:30pm Conference Registration open for All Attendees – Coronado Foyer

PRE-CONFERENCE ELECTIVE CRRT WORKSHOP – DAY 2 (CME Available for a fee)

Practice Based Learning in CRRT: The Science and the Art

Monday MORNING SESSION 2 (Day 2)

8:00am-9:50am IMPLEMENTING CRRT
8:00-8:20 De-escalating and Transitioning RRT – Manish Kaushik
8:20-8:40 Integrating Multidisciplinary Support Team for CRRT Delivery – Linda Awdishu
8:40-9:00 Paper to Digital, e-Prescribing and Charting for CRRT During AKI in the ICU – Theresa Mottes
9:00-9:20 Developing Quality Measures for CRRT Delivery – David Askenazi
9:20-9:35 Introduction to Workshops – Ashita Towani

9:35-9:50 Coffee Break

Monday MORNING SESSION 3

9:50am-12:00pm WORKSHOPS
Rotating at 45 MIN Intervals: 9:50-10:35am; 10:40-11:20am; 11:25am-12:15pm
Breakout Room #1: Knowing your Circuit, Alarms, and Other Tricks – Katrina Eggleston and Katie Plomaritas
Breakout Room #2: The When, How, and Why of CRRT? – Pedro Teixeira and Dana Fuhrman
Breakout Room #3: Citrate Lab and Other Anticoagulation alternatives: Concepts to Build Your Protocol – Lenar Yessayan and Michael Connor

12:15-1:00pm Lunch Hosted by Conference for Workshop Participants

Monday AFTERNOON SESSION 4

1:00pm-3:00pm WORKSHOPS
Rotating at 35 MIN Intervals: 1:00-1:35pm, 1:40-2:15pm, 2:25-3:00pm
Breakout Room #1: Connectology with Hybrid Systems: ECMO, Apheresis, ECCOR – Keith Wille and Katie Plomaritas
Breakout Room #2: Precision Solute Control and Dynamic Dosing with CRRT – Manish Kaushik and Ashita Tolwani
Breakout Room #3: What’s New in Blood Purification in the ICU? – Thiago Reis, Javier Neyra and Raj Basu

3:00-3:15 Coffee Break

Monday AFTERNOON SESSION 5 – NON-CME

3:15-5:30pm INTERACTIVE TRACKS
These sessions will have adult and pediatric tracks to familiarize attendees with the available CRRT machines. Participants will be guided on user inter-faces, learn how to set up for different modalities and adjust and monitor for therapy delivery based on the prescription. Machines connections for combination therapies with ECMO, apheresis and adsorption techniques will be shown.

3:15-4:45 CRRT Equipment Demonstrations Simultaneous – (select one)

Breakout Room #1: Baxter PRISMAX – Michael Connor and Katrina Eggleston
Breakout Room #2: Fresenius NxStage / multiFiltrate Pro – Lenar Yessayan and TBD (multiFiltrate Pro) and TBD (NxStage)
Breakout Room #3: Pediatric Systems – David Askenazi, Dana Fuhrman, Theresa Mottes

4:45-5:30 CRRT MASTER CLASS
In this session participants will be allocated to teams and given a case scenario for which they have to determine an appropriate prescription for CRRT and program the machine to deliver the therapy.

5:30 Adjourn

5:30-7:30pm Monday Evening Reception & Poster Review – For All Conference Attendees

PRE-CONFERENCE AKI SYMPOSIUM (Non-CME)

Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management

Presented by UAB/UCSD O’Brien Center for AKI Research
(AKI & CRRT Conference registration is NOT required to participate)

7:00am-12:00pm Registration Open – For Pre-Conference Events Only – Coronado Foyer

7:55 am Opening Remarks – Ravindra Mehta, MD

PLENARY 1 The Discovery Pipeline: Molecules, Mechanisms and Targets
Co-Chairs: Alex Zarbock and Prabhleen Singh
8:00-8:20 Roles of Lymphatics and Lymphangiogenesis in AKI – Joseph Rutkowski
8:20-8:40 Iron Metabolism in AKI to CKD Transition – Abolfazl Zarjou
8:40-9:00 Enhancing Kidney Repair – TBD
9:00-9:20 Sensing the Pressure: Role of Mechanosensory Channels in Kidney Damage in AKI and CKD – Mark Okusa
9:20-9:40 Cellular and Mitochondrial Dysfunction: Targets for Intervention? – Vincenzo Cantaluppi
9:40-10:00 Discussion
10:00-10:15 Coffee Break

PLENARY 2 Bench to Bedside: Translating Discoveries to Clinical Care
Co-Chairs: Mark Okusa and Volker Vallon
10:15-10:35 Development as a Biological Variable in Experimental Models of AKI – Danielle Soranno
10:35-10:55 The Role of ORAI-1 in AKI – Sudarshan Hebbar
10:55-11:15 Insights for AKI from the Human Kidney Precison Medicine Project (KPMP) – Matthias Kretzler
11:15-11:35 Targeting Mitochondria and Metabolism in AKI – Mark Hepokoski
11:35-11:55 Metabolic Communication Through SGLT2 Inhibition – Volker Vallon
11:55-12:15 Discussion
12:15-1:15 pm Lunch Hosted by Conference

PLENARY 3 Emerging Strategies for AKI Studies
Co-Chairs: Kathleen Liu and Sejoong Kim
1:15-1:35 Nephrons of Steel: Exploring Kidney Fitness and Resistance to Acute Kidney Injury – Dana Fuhrman
1:35-1:55 Clinical Trial Endpoints for AKI: Consensus Recommendations from ADQI – Lui Forni
1:55-2:15 Bayesian Methods: A Potential Path forward for ICU Trials – John Kellum
2:15-2:35 In-Silico Trials in AKI and Sepsis – Gianluca Villa
2:35-2:55 Drug-Induced Acute Kidney Injury Risk Prediction Models – Linda Awdishu
2:55-3:15 Discussion
3:15-3:30 Coffee Break

PLENARY 4 Evolving Paradigms: Lessons from Ongoing Trials
Co-Chairs: Nuttha Lumlertgul and Ron Wald
3:30-3:50 Design and Conduct of the COPE AKI Study: What are we Learning? – Ivonne Schulman
3:50-4:10 Selective Cell Cytopheretic Device for AKI – Stuart Goldstein
4:10-4:30 Towards Health Care Metaverse: Digital Twins in the ICU – Azra Bihorac
4:30-4:50 Refining Inclusion Criteria for AKI Clinical Trials – Glenn Chertow
4:50-5:10 Tackling Heterogeneity: Phenotyping for Hemadsorption – Kent Doi
5:10-5:30 Discussion

5:30 Adjourn

5:30-7:30pm Monday Evening Reception & Poster Review – For All Conference Attendees

PRE-CONFERENCE POCUS WORKSHOP (CME Available for a fee)

Point of Care Ultrasound (POCUS): Science and Practice

8:00am-4:30pm (limited to 40 participants)

This course is designed for nephrology and critical care providers to learn the basics of Point-Of-Care Ultrasound with a specific focus on frequent pathologies found in acutely ill patients. This workshop will include brief didactic sessions and hands-on sessions. At the end of this workshop, the trainees will have basic knowledge about indications for POCUS, normal/abnormal findings, and how this can be integrated in the evaluation of the patients. The aim is to provide the introductory practical skills necessary to continue their training autonomously. A quiz will be administered pre- and post-course for assessment.

Faculty: W. Beaubien-Souligny; K. Kashani; A. Shaw, R. Wald; J. Deschamps; V. Niyyar, P. Teixeira

Learning Objectives:
The core focus on this course is as follows:

1. Cardiac: A. Qualitative assessment of chamber size and systolic function; B. Identification of severe valvulopathy; C. Assessment of pericardial fluid and tamponade physiology
2. Thoracic: A. Qualitative assessment of pleural effusion size and characteristics; B. Identification of pneumothorax; C. Assessment of alveolar consolidation and interstitium
3. Abdominal: A. Identification of kidney and bladder and assessment of kidney size and echogenicity, and evaluation of urinary obstruction; B. Identification of intraperitoneal fluid; C. Qualitative assessment of abdominal aorta size
4. Vascular and Vascular Access: A. Patency and caliber of main veins for catheter placement; B. Identifying the presence of a thrombus; C. Basic examination of an arteriovenous fistula/graft
5. Hemodynamic and Fluid Evaluation: A. Inferior vena cava visualization and assessment; B. Venous Doppler assessment; C. Estimating stroke volume / cardiac output

Schedule
Participants will be allocated into groups of 4 and will rotate through each of 5 stations to review the principles of image identification and interpretation and get hands-on experience with the ultrasound probes.

8:00-8:20am Welcome and Pre-quiz
8:20-8:45 Introduction to Basics of Lung Ultrasound
8:45-9:15 Lungs: Hands-on (group 1) / Image Review Session (group 2)
9:15-9:45 Lung Part 2 (group switch)
9:45-10:00 Coffee Break
10:00-10:20 Introduction to Basic Echocardiography
10:20-10:50 Heart: Hands-on (group 1) / Image Review Session (group 2)
10:50-11:10 Heart Part 2 (group switch)
11:10-12:30 Vascular Ultrasound and Vascular Access
12:30-1:15 Lunch Hosted by Conference for Workshop Participants
1:15-1:35 Introduction to Abdominal and Renal Ultrasound
1:35-2:05 Abdomen: Hands-on (group 1) / Image Review Session (group 2)
2:05-2:35 Abdomen Part 2 (group switch)
2:35-2:50 Coffee Break
2:50-3:10 Introduction to Fluid Status Assessment: Putting it all together
3:10-3:40 Fluid Assessment: Hands-on (group 1) / Image Review Session (group 2)
3:40-4:10 Fluid assessment 2 (group switch)
4:10-4:30 Post-quiz and Conclusion
4:30 Adjourn

5:30-7:30pm Monday Evening Reception & Poster Review – For All Conference Attendees

Tuesday Morning, March 4, 2025

7:00am-7:30pm Conference Registration Open

MEET THE EXPERT Elective Breakfast Sessions – Group 1 (CME Available)
7:00-8:00am
(choose one)
7:00-8:00am
Session 1 (ME1) – How do I use Hemadsorption Techniques in My Practice
Claudio Ronco and Thomas Rimmelé

7:00-8:00am
Session 2 (ME2) – How Do I use ChatGpt to Help Me Work Smarter?
Azra Bihorac and Rolando Claure-Del Granado

7:00-8:00am

MORNING SYMPOSIA – (CME Available for A and B)
(Seating is LIMITED, selection made during registration, coffee served)

Symposium A – De-escalating and Transitioning RRT: Best Practices
Ron Wald and Anitha Vijayan (Moderators)
The practice of transitioning between RRT modalities and discontinuing RRT varies widely across different centers. Due to a lack of guidelines, care delivery often relies on subjective assessments of the patient’s condition. This symposium will explore the evidence for weaning patients from acute RRT and discuss the transition between different RRT modalities.

Modality Transitions for RRT: What do I do – Ashita Tolwani
Discontinuation of RRT – When and How – Sean Bagshaw
Liberation off CRRT – Strategies to Optimize Care in Children – Shina Menon

Symposium B – Utilizing Biomarkers for AKI Management: Practical Considerations
John Prowle and Mitra Nadim (Moderators)
Current paradigms for diagnosing, staging, and monitoring kidney function changes from AKI rely on serum creatinine and urine output, which often do not correlate with underlying structural damage. The availability of various biomarkers of kidney function and damage offers new approaches for patient evaluation and targeted interventions. This symposium will discuss practical ways to incorporate biomarkers to enhance management of AKI.

Determine High Risk Patients and Intervention Strategies – Alex Zarbock
Implementing Dialysis Timing with Biomarker Guidance – Rajit Basu
Assessing Recovery and Treatment Response to Intervention – Christian Nusshag

OPTIONAL INDUSTRY BREAKFAST SYMPOSIUM (Non-CME)
S1 – Click Here for Details

SESSION I: PATIENT CHARACTERISTICS (CME Available)

8:20-10:30am
Plenary 1 – MINI-SYMPOSIA
Organ Dysfunction in the Critically Ill Patient: Emerging Concepts
Co-Chairs: Neesh Pannu and Michael Joannidis

8:20-8:30 Opening Remarks – Ravindra L Mehta
8:30-8:45 Worsening Kidney Function in Acute Heart Failure – Amir Kazory
8:45-9:00 Refractory Shock: Can we Define it? – Ashish Khanna
9:00-9:15 Neural Control of Multiorgan Dysfunction in AKI – Mark Okusa
9:15-9:30 Lactate in Critical Illness – Marlies Ostermann
9:30-9:45 Sepsis Associated AKI: What Have we Learned? – Matthieu LeGrand
9:45-10:00 New Insights in Thermoregulation – Peter Pickkers
10:00-10:30 SPECIAL LECTURE

AI in the ICU: Are We Ready?
Yes: Azra Bihorac
Maybe: Jay Koyner
No: Lui Forni
Moderator: Claudio Ronco

10:30-11:00 Coffee Break
Faculty Picture

SIMULTANEOUS STANDARD WORKSHOPS (CME Available)
Open to all participants (applicable to physicians, nurses and allied personnel)

These Standard Workshops are designed for smaller groups and allow for more interaction between presenters and attendees. Ample time is available for Q&A.
Codes: C= Core workshop, I = Intermediate, A = Advanced, N= Nurses, AP = Nurses & Allied Personnel

Workshop Tracks
A: AKI; B: CRRT Technique; C: Critical Care Topics ; D: Organ Support

11:00am-12:30pm
Standard Workshops – Group 1 (Choose 0ne)

A01 Enhancing Communication in the Workplace: Improving Skills with Empathy (C,N,AP)
This experiential workshop aims to enhance patient care by fostering curiosity, listening, and perspective-taking skills. It will help participants develop competence in addressing communication challenges. Through brief interactive didactics, medical improv, and reflective exercises, we will improve skills essential for care providers and team members. Additionally, we will explore how implicit bias affects communication through prejudices, stereotyping, or discrimination. (G. Mehta, JM Maury) Limited to 30 participants

B02 Citrate Anticoagulation for CRRT: How to Use it? (C,N,AP)
Regional citrate anticoagulation (RCA) is increasingly utilized for CRRT. Advances in technology have enabled automated citrate anticoagulation. However, concerns remain about its ease of use and application in patients with liver failure and reduced tissue perfusion. This workshop will discuss the best approaches for utilizing RCA for CRRT. (Tolwani, Joannidis, Srisawat)

C03 Pediatric AKI and RRT: Beyond the Basics (I,N,AP)
This workshop will highlight the epidemiology and best practices for AKI management and CRRT, peritoneal dialysis and tandem therapies application in neonates and children. (Plomaritas, Selewski, Soranno)

D04 Managing Patients with Combined Kidney and Liver Failure (C,N,AP)
Patients with combined liver and kidney failure are difficult to manage. This workshop will discuss the pathophysiology and illustrate best approaches for differential diagnosis and management of these patients. (Nadim, Deep, Rosner)

12:30-2:00pm LUNCH SYMPOSIA – (Non-CME)
(Seating is LIMITED, selection made during registration, lunch provided by conference.)
Please note: At this time, these are the only lunch options provided on Tuesday.

Establishing Evidence for Interventions for AKI and CRRT: Trial Designs and Endpoints
Currently, no specific therapy exists for preventing or treating AKI other than mitigating further injury and providing supportive care. Clinical trials in AKI and CRRT have largely been unsuccessful in providing evidence for novel therapeutic interventions targeting underlying pathophysiology. This symposium will discuss the rationale and adoption of new, well-designed clinical trials with appropriate endpoints to confirm or refute the efficacy of such interventions.
Moderators: Glenn Chertow and Kathleen Liu

Sex and Gender Considerations in Critical Care Nephrology Trials – Nuttha Lumlertgul
Endpoints for AKI Trials – Time for a MAKE-over? – Andrew Shaw
Clinical Trial Designs: ADQI Recommendations – Alex Zarbock

T2 Improving Care for Patients After Hospitalization for AKI
AKI is a complex disease that requires multidisciplinary interventions however most patients who are hospitalized with an episode of AKI do not have systematic follow up or targeted interventions to improve recovery and mitigate the effects of the disease. This session will provide guidance on patient centered approaches to improve the management and outcomes of patients with AKI.
Moderators: Jorge Cerda and Samira Bell

Developing a Post-AKI follow-up Clinic – Real-life Experience – Nick Selby
Barriers to Effective Patient Education and Follow-up in AKI Recovery – Etienne Macedo
Post-Hospitalization of Patients with AKI Requiring Dialysis – Anitha Vijayan

OPTIONAL INDUSTRY LUNCH SYMPOSIA – (Non-CME)
I1 TBD Click Here for Details
I2 TBD Click Here for Details

SIMULTANEOUS STANDARD WORKSHOPS – (CME Available)

2:00-3:30pm
Standard Workshops – Group 2 (Choose One)

A05 Enhancing Communication in the Workplace: Addressing Conflict and Uncertainty (C,N,AP)
Patients’ emotional responses to illness, along with clinicians’ reactions, are central to healthcare communication. Strong emotions significantly influence decision-making and clinical outcomes. Recognizing, validating, and managing negative emotions in patients is crucial. This workshop wil provide brief didactics and reflections, share strategies for empathic communication, and explore ways to maintain our own emotional regulation.(G Mehta, Fuhrman) Limited to 30 participants

B06 Precision Solute Control and Dynamic Dosing with CRRT? (I,N,AP)
CRRT techniques have evolved with availability of new technology to customize dialysis delivery. This interactive case based workshop will discuss how to apply the technology for dose adjustments, monitoring for adequacy, modality selection and transitions in CRRT. (Claure, Kaushik, Prowle)

C07 Starting, Transitioning and Stopping RRT for AKI: Science and Art (C,N,AP)
One of the most vexing issues for clinicians is determining when to initiate RRT in critically ill patients, when and how to transition modalities and when it can be stopped. This workshop will use case studies to explore various approaches and establish the principles for clinical decisions for renal support. (Mehta, Bagshaw, Lumertgul)

D08 Hemadsorption: Techniques and Application (ECOS) (C,N,AP)
Hemadsorption techniques have advanced with the development of selective membranes for extracorporeal organ support. These methods are now widely used, often alongside standard CRRT. This workshop will cover the rationale and strategies for practical application, using case studies to explore different options. (Ronco, Reis, Rimmelé)

3:30-4:00pm Coffee Break

SESSION I: PATIENT CHARACTERISTICS – continued (CME Available)

4:00-6:00pm
Plenary 2 – MINI-SYMPOSIA
Acute Kidney Injury (AKI): Pathophysiology
Co-Chairs: Danielle Soranno and Kent Doi

4:00-4:15 Adenosine Antagonists and the Kidney – David Askenazi
4:15-4:30 The Emerging Concept of Tubular Functional Reserve – Vincenzo Cantaluppi
4:30-4:45 AKI in the Neurosurgical Unit – Vedran Premuzic
4:45-5:00 Urine Profiling in Sepsis – Associated AKI – Christian Nusshag
5:00-6:00 SPECIAL SESSION

30 Years of AKI and CRRT: Reflections and Predictions
Panel: Claudio Ronco, Tim Bunchman, Ravindra Mehta, Glenn Chertow & TBD
Moderators: Stuart Goldstein & Marlies Ostermann

6:00pm Adjourn

6:00-8:00pm EXHIBIT RECEPTION AND POSTER SESSION

Wednesday Morning, March 5, 2025

7:00am-6:00pm Conference Registration Open

MEET THE EXPERT Elective Breakfast Sessions – Group 2 (CME Available)
7:00-8:00am
(choose one)
7:00-8:00am
Session 3 (ME3) – How do I Monitor Quality for CRRT in my ICU
Theresa Mottes and Oleksa Rewa

7:00-8:00am
Session 4 (ME4) – How do I Manage the Oliguric Patient?
Ashish Khanna and Lui Forni

7:00-8:00am

MORNING SYMPOSIA – (CME Available)
(Seating is LIMITED, selection made during registration, coffee served)

Symposium C – Nutritional Strategies for AKI and CRRT: Can We Improve Outcomes?
Michael Connor and Linda Awdishu (Moderators)
Patients with AKI often experience malnutrition due to altered nutrient metabolism and nutrient loss associated with RRT. Recent trial data suggests that adjusting protein and energy intake is crucial for improving outcomes in these patients. This symposium will review the latest findings on nutrition and discuss current official recommendations.

Assessing Nutritional Status and Needs in the ICU – Michael Joannidis
The Who, When and How of Nutritional Support for AKI and CRRT – Marlies Ostermann
Protein, Urea and Outcomes in AKI – John Prowle

Symposium D – Managing the Heart Failure Patient with Worsening Renal Function
Patrick Murray and Raj Chakaravarthi (Moderators)
Patients with advanced heart failure often develop worsening renal function (WRF), making it challenging to decide between drug therapy and RRT. This workshop will cover practical applications and outcomes of various treatments for heart failure and cardio-renal syndrome, including ultrafiltration techniques.

Assessing Cardiac Function – What Tools? – Jean Deschamps
Improvement in Renal Function: Is It a Good Thing in Acute Heart Failure? – Amir Kazory
Is Urine Sodium Effective at Guiding Decongestion? – Rolando Claure-Del Granado

SIMULTANEOUS STANDARD WORKSHOPS (CME Available)
Open to all participants – applicable to physicians, nurses and allied personnel
Codes: C= Core workshop, I = Intermediate, A = Advanced, N= Nurses, AP = Nurses & Allied Personnel

Workshop Tracks
A: AKI; B: CRRT Technique; C: Critical Care Topics ; D: Organ Support

8:15-9:45
Standard Workshops – Group 3 (choose one)

A09 Enhancing Communication in the Workplace: When Something Goes Wrong (C,N,AP)
Despite our best efforts, patients sometimes face unintended negative consequences from care or treatment. It is our professional duty to disclose adverse events and near misses to patients and their families with honesty. This workshop will provide evidence-based communication tools to help offer apologies, share necessary information, and provide emotional support and resources. We will use clinical scenarios and role-plays to address challenges and manage these conversations effectively. (G. Mehta, Ostermann)

B10 Personalized Fluid Management with CRRT (A,N,AP)
Achieving fluid balance and maintaining plasma composition is key for effective CRRT. This workshop will use case studies to discuss strategies for fluid management in CRRT to achieve patient driven outcomes for fluid, electrolyte and acid base balance. (Murugan, Mehta, Beaubien-Souligny)

C11 Optimization of the CRRT Program to Improve Outcomes (A,N,AP)
Although RRT is widely applied globally, there are minimal established criteria for monitoring care quality. This symposium will outline the characteristics of top-tier CRRT programs and strategies for Quality Improvement by integrating data from CRRT devices and clinical information. The importance of policies, procedures, and dashboards will also be discussed. (Neyra, Mottes, Rewa)

D12 Plasma Exchange in Critically Ill Patients: Who, When and How (A,N,AP)
Plasma exchange (PE) is increasingly utilized in the ICU with CRRT and other extracorporeal techniques. This workshop will describe the best approaches for applying PE in critically ill patients and explore merging opportunities for managing patients with hybrid therapies. (Sanchez, Premuzic, Noiri)

9:45-10:15am Coffee Break

SESSION II: CONTROVERSIES IN CRITICAL CARE NEPHROLOGY (CME Available)

10:15am-12:30pm
Plenary 3 – MINI-SYMPOSIA
Challenges in ICU Management
Co-Chair: Peter Pickkers and Nuttha Lumlertgul

10:15-10:30 Post-op Vasopressors Use and the Kidneys: Is There a Problem? – Lui Forni
10:30-10:45 SGLT2 Inhibitors and Critical Illness – Marlies Ostermann
10:45-11:00 Intra-abdominal Hypertension and Renal Perfusion Pressure: Targets for Intervention? – Ashish Khanna
11:00-11:15 Understanding Kidney Health During and After Critical Illness – John Prowle
11:15-11:30 Immune Disorders of AKI Patients Following Various Types of Injuries – Thomas Rimmelé
11:30-11:45 Hepatorenal Syndrome: Changing Paradigms – Mitra Nadim
11:45-12:15 SPECIAL LECTURE

San Diego AKI & CRRT Award
Translating Discoveries to Enhance Management in AKI
TBD

12:15-12:30 Top Abstract Awards

Wednesday AFTERNOON

LUNCH SYMPOSIA – (Non-CME)
(Seating is LIMITED, selection made during registration, lunch provided by conference.)
Please note: At this time, these are the only lunch options provided on Wednesday.

12:30-2:00pm

W1 Chat GPT is Here to Stay: What Can We Expect?
The use of ChatGPT and similar AI tools is growing across various aspects of our lives. Despite being in the early stages of acceptance, these tools are being adopted in healthcare for quick access to medical information, generating patient summaries, suggesting diagnoses, and providing treatment options. This symposium will explore the emerging applications and practical issues of these techniques in managing ICU patients.
Moderators: Jay Koyner and Nuttha Lumlertgul

AI for Continuous Acuity Prediction in the ICU – Azra Bihorac
AI Generated Risk Score for Acute Kidney Injury Prediction – Rolando Claure-Del Granado
ChatGPT applications in Critical Care Nephrology – Kianoush Kashani

W2 AKI Post Transplant: Recognition and Management
Acute kidney injury (AKI) frequently occurs in recipients of solid-organ transplants, such as kidney, heart, lung, and liver transplants. In addition to the typical causes of AKI in native kidneys, transplanted organs have unique risk factors. This symposium will cover the epidemiology, clinical significance, and pathogenic mechanisms of AKI, as well as the impact of immunosuppressive therapies on these patients.
Moderators: Keith Wille and Vandana Niyyar

Post Non-Kidney Solid Organ Transplant AKI: Patterns and Outcomes – Raj Chakaravarthi
AKI Post Kidney Transplant – Vincenzo Cantaluppi
Pediatric Post Transplant AKI – Akash Deep

OPTIONAL INDUSTRY LUNCH SYMPOSIA – (Non-CME)
I3 TBD  Click Here for Details
I4 TBD  Click Here for Details

SESSION III: EMERGING CONCEPTS IN AKI AND RRT (CME Available)

2:00-3:45pm
Plenary 4 – MINI-SYMPOSIA
Novel Strategies in AKI Management
Co-Chairs: Samira Bell and Javier Neyra

2:00-2:15 Early Detection of Drug-induced Kidney Injury (DIKI): Role of Biomarkers – Patrick Murray
2:15-2:30 Role of Renal Functional Reserve on AKI Risk and Recovery – Claudio Ronco
2:30-2:45 How Best to Assess Renal Recovery after AKI – Nick Selby
2:45-3:00 AKI – Is it All the Same? – Alex Zarbock
3:00-3:15 Preventing Cardiac Surgery AKI: Do we have a Solution – Andrew Shaw
3:15-3:30 Temporary Mechanical Circulatory Support and the Kidney – Jean Deschamps
3:30-3:45 Management of RAAS Inhibitors in the Pre-op Setting – Matthieu LeGrand

3:45-4:15 Coffee Break

4:15-6:00pm
Plenary 5 – MINI-SYMPOSIA
Challenges and Controversies in Renal Support and CRRT
Co-Chairs: Anitha Vijayan and Nattachai Srisawat

4:15-4:30 ECMO and CRRT: Synergism or Dissonance – David Selewski
4:30-4:45 Net Balance vs Net UF: What Matters? – Ravindra Mehta
4:45-5:00 Starting RRT for AKI: How Late is too Late? – Ron Wald
5:00-5:15 Effect of Ultrafiltration Rates on Kidney Recovery Post AKI – Etienne Macedo
5:15-5:30 RRT Dose-Intensity in AKI – Time to Revisit – Sean Bagshaw
5:30-5:45 PIRRT in Critical Care: Does it have a Role? – Eric Hoste
5:45-6:00 ADQI 34: Renal Toxicity Due to Anti-Cancer Therapies – Mitch Rosner

6:00 Adjourn – Free Evening

Thursday Morning, March 6, 2025

7:00am-1:00pm Conference Registration Open

MEET THE EXPERT – Elective Breakfast Sessions – Group 3 – (CME Available)
7:00-8:00am
(choose one)
7:00-8:00am
Session 5 (ME5) – How do I care for the Patient with ARDS and AKI
Kathleen Liu and Keith Wille

7:00-8:00am
Session 6 (ME6) – How do I Dose Volume During CRRT?
Raghavan Murugan and David Selewski

7:00-8:00am

MORNING SYMPOSIA – (CME Available)
(Seating is LIMITED, selection made during registration, coffee served)

Symposium E – Adapting CRRT for Patients with Electrolyte and Acid Base Problems
Pedro Teixeira and Harin Rhee (Moderators)
Acid base and electrolyte problem are commonly encountered in critically ill patients and are often the reason for initiating CRRT. This symposium will discuss three common situations in ICU patients and provide guidance on best practices for recognition and management.

Bicarbonate in AKI: Use and Misuse – Lui Forni
Dysnatremias: How to Correct with CRRT – Lenar Yessayan
Phosphorus and Magnesium Abnormalities During CRRT – Mitch Rosner

Symposium F – Assessment of Fluid Responsiveness, Hemodynamic Monitoring and Targets
Matthieu Legrand and Akash Deep (Moderators)
Fluid administration is an integral component of management of critically ill patients. Determining which patient needs fluids, what type, when and how much is crucial for optimal management. This symposium will cover the principles and strategies for volume assessment and hemodynamic monitoring in ICU.

Assessing Volume Status in the ICU Patient: Tools and Strategies – Kianoush Kashani
POCUS for Fluid Management: Can it Guide Therapy? – William Beaubien-Souligny
Hemodynamic Monitoring: What Metrics Should We Follow? – Eric Hoste

SESSION IV: IMPROVING OUTCOMES IN AKI (CME Available)

8:00-10:30am
Plenary 6 – MINI-SYMPOSIA
Global Burden of AKI
Co-Chair: Raj Chakaravarthi and Etienne Macedo

8:00-8:15 Effects of AKI in Liver Disease – Akash Deep
8:15-8:30 Inequalities in Healthcare and Effects on Kidney Disease – Samira Bell
8:30-8:45 Changing Epidemiology of AKI: What have we Learned? – Jorge Cerda
8:45-9:00 Advances in Pediatric AKI – Timothy Bunchman
9:00-9:15 Heat Stress and Kidney Dysfunction – Emmanuel Burdmann
9:15-9:30 TBD
9:30-9:45 Greening CRRT: Opportunties and Challenges – Harin Rhee
9:45-10:00 Acute PD vs Acute HD: Which is the Right Choice? – Nattachai Srisawat
10:00-10:15 Controversial Issues in CKRT: Insights from Korean Guidelines – SeJoong Kim
10:15-10:30 ADQI 35: Accelerating the Adoption of Evidence-based Practices in AKI – Javier Neyra and Oleksa Rewa

10:30-11:00 Coffee Break

SESSION V: FUTURE TRENDS IN CRRT AND CRITICAL CARE (CME Available)

11:00am-1:00pm
Plenary 7 – MINI-SYMPOSIA
Emerging Strategies in AKI and Extracorporeal Support
Co-Chairs: Thiago Reis and Harin Rhee

11:00-11:15 New Horizons in AKD Care and Prevention – Vincent Wu, MD
11:15-12:30 Update from Ongoing and Late Breaking Trials
(8-10 minutes each)

1. The RELIEVE-AKI Trial – Raghavan Murugan
2. The ESTOP AKI Trial – Jay Koyner
3. LIBERATE-D Trial – Kathleen Liu
4. HERICC REGISTRY: PHASE 2 – Vedran Premuzic
5. Bicarbonate in CRRT Trial – Michael Joannidis
6. Dialyzing Wisely Program – Oleksa Rewa
7. TIGRIS Trial – Matthieu Legrand
8. KOURAGE Trial – Patrick Murray
9. AM Pharma Trial – Peter Pickkers

12:30-12:55 Critical Care Nephrology: Literature Review – Kianoush Kashani
12:55-1:00 Closing Remarks – Ravindra L. Mehta Chairman
1:00pm Conference Adjourns